Marie Curie PhD fellowship in NAD and Aging (DNA damage)

Updated: 3 months ago
Deadline: 06 Dec 2022

Center for Healthy Aging
Department of Cellular and Molecular Medicine (ICMM)
Faculty of Health and Medical Sciences
University of Copenhagen

We are offering a PhD fellowship in Aging commencing April 1, 2023, or after agreement.

Our group and research
Our group ( approx. 15 people) utilizes computational science, animal models, and clinical trials to understand and manipulate the aging process with a particular focus on the role of DNA damage in aging. We develop and utilize high-throughput approaches such as high-content microscopy and omics investigations to understand the molecular basis of aging and age-associated phenotypes. Lab generated data is routinely analysed through AI-assisted pipelines such as novel cellular senescence classifiers and fully automated animal tracking ( ).

Project description
DNA damage accumulates with age and may contribute to age-associated diseases. A major DNA damage responsive enzyme is poly-ADP-ribose polymerase 1 (PARP1). Activation of PARP1 may contribute to decline of NAD with age however it is unclear how PARP activation can contribute with this in a steady state system. This PhD project will focus on understanding how DNA damage might impact systemic changes in NAD levels across tissues, a critical point for our ability to treat age-associated diseases.

This project is funded through the EU-Horizon NADis Marie Skłodowska-Curie Network (grant agreement #101073251) and the chosen candidate will become part of a larger network of researchers across top universities in Europe. NADIS is a MSCA Doctoral Network .

The NADIS network
The main goal of the NADIS consortium is to train the next generation of metabolic researchers, providing them with in-depth knowledge and cross-disciplinary expertise to combat disease. The research projects will specifically focus on the metabolism of NAD+, a central redox cofactor and enzymatic substrate that plays an essential role in virtually all major cellular functions. The limited knowledge on the interplay between NAD+ and the cellular processes in which it is involved, especially those that lead to disease, requires novel experimental and analytical tools combined with a strong interaction between scientists and clinical staff coming from different disciplines. We aim to fill these gaps by training ten highly skilled ESRs. To do this, we bring together our expertise in molecular and cellular biology, bioinformatics, and Artificial Intelligence (AI), omics, drug development and nutritional/clinical applications. Our non-academic beneficiaries are focused on the development of nutrition products, medical foods, and drug development for new therapies. We will also provide ESRs with transferable and networking skills, and first-hand experience of industrial applications, enabling them to become future leading scientists at the forefront of metabolic research and, specifically, NAD+ research in Europe.

Principal supervisor is Morten Scheibye-Knudsen, Center for Healthy Aging, email , or phone: +45 4250 7060.

Start:            1 April 2023 or after agreement

Duration:     3 years as a PhD Fellow

Job description
Your key tasks as a PhD Fellow at SUND are:

  • Carrying through an independent research project under supervision
  • Completing PhD courses or other equivalent education corresponding to approximately 30 ECTS points
  • Participating in active research environments including a stay at a NADis member
  • Obtaining experience with teaching or other types of dissemination related to your PhD project
  • Teaching and disseminating your knowledge
  • Writing a PhD thesis on the grounds of your project

Key criteria for the assessment of applicants
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project e.g., please note that your master’s degree must be equivalent to a Danish master’s degree (two years).

Other important criteria are:

  • A passion for aging research
  • Knowledge of the DNA repair field
  • Experience working with mice
  • Experience working with cells

Place of employment
The place of employment is at the Center for Healthy Aging, Department of Cellular and Molecular Medicine (ICMM), Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment.

Scientific environment
The Department of Cellular and Molecular Medicine (ICMM) offers an ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components, and molecular cellular mechanisms in a medical context.

ICMM currently comprises five research programmes, three high profile Research Centers as well as several international research groups. The scientists at ICMM are involved in high quality research based undergraduate and graduate teaching programs at the University of Copenhagen.

You can read more at .

Terms of employment
The average weekly working hours are 37 hours per week. The position is a fixed-term position limited to a period of 3 years. The start date is April 1, 2023.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the faculty’s rules on achieving the degree.

Salary, pension, and terms of employment are in accordance with the agree­ment between the Ministry of Taxation and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary starts at DKK 28,448 / approx. EUR 3,818 (October 2022 level) plus pension.

For specific information about the PhD fellowship, please contact the principal supervisor.

General information about PhD studies at the Faculty of Health and Medical Sciences is available at the Graduate School’s website .

Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format: 

  • Motivated letter of application (max. one page).
  • CV incl. education, experience, language skills and other skills relevant for the position.
  • Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted. As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: . Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.
  • Publication list (if possible)
  • Application deadline: Tuesday, December 6, 2022, at 23.59 p.m. CET.

    We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

    The further process
    After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

    The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

    Once the assessment work has been completed each applicant can comment on the part of the assessment that relates to the applicant him/herself.

    You find information about the recruitment process at .

    The applicants will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

    Interviews are expected to be held in the first weeks of January 2023.

    The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background. 

    Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

    View or Apply

    Similar Positions