Fully-funded postdoc position in cell signaling/epigenetics/quantitative proteomics

Updated: about 1 year ago
Deadline: 24 Jul 2019

A highly attractive postdoctoral position is available in the Choudhary Group at the Novo Nordisk Foundation Center for Protein Research (CPR – www.cpr.ku.dk ), University of Copenhagen. 

About the group
The Choudhary laboratory is technically and internationally diverse, and embedded in excellent environment that supports high-quality research and encourages interdisciplinary collaboration. This is clearly reflected by the group’s extensive collaboration with top-level international researchers, publications in top-ranked journals, and an outstanding track-record in training the next generation of researchers. The lab works closely with almost all other groups at CPR, especially with the “Clinical Proteomics” group led by Prof. Matthias Mann.

In our lab, we combine interdisciplinary technologies for systematic mapping of posttranslational modifications and protein-protein interactions relevant to specific biological pathways and processes (Narita et al. Nat Rev Mol Cell Biol 2019; Weinert and Narita et al., Cell 2018; Gupta et al., Cell 2018; Wild et al., Cell Rep 2016 and 2018; Scholz et al., Nat Biotech 2015; Choudhary et al., Nat Rev Mol cell Biol 2014 and 2010; Weinert et al., Mol Cell 2013; Povlsen and Beli et al., Nat Cell Biol 2012; and Beli et al. Mol Cell 2012). In addition to the state-of-the-art quantitative mass spectrometry, the laboratory is equipped with the cutting-edge infrastructure for molecular biology, cell biology and biochemistry work. Furthermore, CPR offers the latest technologies and expertise for the next-generation DNA/RNA sequencing, high-resolution microscopy, as well as the technologies for biophysical and structural characterization of proteins, including Cryo-EM. Our main models of study are human/mouse cell lines and murine embryonic stem cells (mESCs).

We are now looking for enthusiastic candidates with a PhD and/or MD to join our lab.

Project description
The group is broadly interested in studying cellular signaling networks related to protein ubiquitylation/acetylation/epigenetics/ and functional analysis of novel proteins. The postdoc fellow will use a combination of quantitative proteomics and CRISPR-based genome editing to address fundamental biological questions in one of the above indicated areas. Among other tasks, this will include generation of genetically modified cell lines, and mass spectrometry-based analysis of posttranslational modifications and protein-protein interactions. The candidate is expected to apply various biochemical and molecular biology approaches for biological follow-up experiments on novel and interesting findings derived from large-scale proteomic screens. If you want to know more about our projects, contact us!

Tentative start date: Late summer 2019.

The candidate should have demonstrated excellent scientific productivity, evidenced by high-quality research publications, be able to conduct independent and creative research, and show good inter-personal and communication skills.

  • The candidate is required to have a PhD/MD or equivalent degree in natural or medical science.
  • Excellent scientific track-record, including at least one publication as first author in a high-quality, peer reviewed international journal.
  • Expert knowledge in one or more of the following areas would be considered an advantage:
         Analysis of cell signaling with biochemistry and molecular biology approaches
    Epigenetics/chromatin biology/genome integrity/DNA damage replication and repair.
    Cell biology, biochemical analysis of protein activity and function
    Molecular biology/CRISPR-based genome editing
    Analysis of large-scale proteomic and/or genomic dataset.
  • Prior experience in high resolution mass spectrometry is not essential.
  • Good communication skills, both oral and written.
  • An analytical aptitude for devising innovative scientific or technical solutions.
  • Demonstrate enthusiasm, motivation, flexibility and confidence.

For further information, please contact Professor Chuna Ram Choudhary by e-mail: chuna.choudhary@cpr.ku.dk . 

Place of employment and work
The employment is at CPR (www.cpr.ku.dk ), University of Copenhagen, located in central Copenhagen. In the past 10 years, CPR has established itself as a top-level research institute in protein signaling and network biology research. The research environment at CPR is ambitious and international, with approx. 30 different nationalities currently represented. The Center comprises modern laboratories, supercomputer resources and state-of-the-art research facilities. Seminars with high-profile international speakers and regular internal research seminars are organized at the Center. Denmark is often ranked as the happiest nation and Copenhagen is consistently ranked as one of the best cities for living.

For more information on working and living in Denmark visit www.ism.ku.dk (International Staff Mobility) and www.workindenmark.dk .

Terms of salary and employment
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary is approx. DKK 34,079 (approx. EUR 4,543) plus 17.1 % in pension contribution.

The Danish Ministry of Finance and the Danish Confederation of Professional Associations (AC) have agreed on a protocol that makes it possible for all international researchers employed by the University to achieve a pension exemption, where the pension can be paid out as salary. For more information about the different pension schemes: https://ism.ku.dk/salary-tax-pension/pension/ .

Duration: The duration of the position is 2 years with a possible extension for up-to two years (depending on the performance, and previous employment at the University of Copenhagen).

Application procedure
Your application must be submitted electronically by clicking ‘APPLY NOW’ below.

Your application should include the following documents:

  • Cover letter.
  • Curriculum vitae, incl. educational qualifications, experience and a list of publications where it shows that the candidates have published at least one publication as first author.
  • A scanned copy of the final degree (PhD or equivalent) certificate. If the degree is not yet awarded, it is sufficient to mention in the cover letter when the applicant expects to submit thesis, and/or receive the qualifying degree.
  • Names and contact details for 2-3 referees.
  • The applicants can submit these materials in the given fields in the online submission system. We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements and that do not have a least one publication as first author.

    Deadline for applications: July 24, 2019, 23:59 p.m. CET.

    After the expiry of the application deadline, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/ . 

    For further information about the position or the process or if you experience any technical difficulty with the online submission system, please contact SUND HR: sund-hr-cpr@sund.ku.dk .

    CPR and the University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.

    Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

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