The successful candidate will be member of the Laboratory of Ligand Engineering at the Institute of Biotechnology (IBT) and involved in Research project “Small binding proteins targeting PD-1/PD-L1 immune checkpoint proteins as new diagnostic tools” (2021-2024) supported by Ministry of Health.
The selected candidate will work with highly complex combinatorial libraries derived from protein domain scaffolds and will use methods of directed evolution of proteins and selection techniques for the identification of promising small protein binders targeting PD-L1 oncomarker and PD-1 T-cell receptor for improved diagnostic of non-small cell lung cancer (NSCLC). He/she will be responsible for protein production, characterization of selected variants by biochemical and biophysical methods, ELISA-related approaches and by LigandTracer-assisted cell-surface binding assay. Tissue penetration of the developed protein diagnostics will be verified in relevant mouse models. The candidate will also be involved in testing of best protein binders in clinical samples of NSCLC patients in collaboration with Faculty Hospital in Olomouc.
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