ShanghaiTech University - Lab at the iHuman Institute
The newly launched ‘Organoid Models of Regeneration and Disease’ lab at iHuman Institute, ShanghaiTech University is actively seeking highly motivated, successful, and creative Postdoc(s) with a background in molecular/cancer biology.
About the Organoid Models of Regeneration and Disease Lab
The Leushacke lab studies the molecular mechanisms of tissue regeneration and disease of various organs. Our experimental strategy involves the combined use of: (1) in vivo animal models and (2) invitro mouse and human organoid models that recapitulate key aspects of mouse and human development, adult tissue homeostasis, regeneration and disease.
The lab’s overarching aim is to understand how stem cells, which play instrumental roles during organogenesis, adult homeostasis, are regulated at the molecular level. During embryonic development, members of the WNT family of secreted signaling molecules induce transcriptional programs that control cell proliferation, cell survival, cell fate determination, and tissue patterning. In adults, the WNT pathway governs stem cell niches in several organs, including the intestine and stomach, ensuring tissue homeostasis. Deregulation of the WNT pathway contributes to developmental defects as well as to the initiation and progression of human diseases including several types of cancer.
Applicants should refer to the following publications
1. RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.
Szenker-Ravi E*, Altunoglu U*, Leushacke M*, et al., Nature. 2018 May;557(7706):564-569. doi: 10.1038/s41586-018-0118-y. Epub 2018 May 16.
( * joint first authors)
2. The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.
de Lau W, Peng WC, Gros P, Clevers H.
Genes Dev. 2014 Feb 15;28(4):305-16. doi: 10.1101/gad.235473.113.
3. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
de Lau W, et al., Nature. 2011 Jul 4;476(7360):293-7. doi: 10.1038/nature10337.
4. Lgr5-Expressing Chief Cells Drive Epithelial Regeneration and Cancer in the Oxyntic Stomach.
Leushacke M, et al., Nat Cell Biol. 2017 Jun 5. doi: 10.1038/ncb3541.
5. Ex vivo culture of the intestinal epithelium: strategies and applications.
Leushacke M, et al., Gut. 2014 Aug;63(8):1345-54. doi: 10.1136/gutjnl-2014-307204.
Candidates should be self-motivated and with a track record of high impact publications. A strong background in cell, molecular and cancer biology is desired. Priority will be given to candidates with demonstrated experience in mouse and organoid biology.
The successful candidate will pursue innovative biomedical research that exploit transgenic mouse lines and ex vivo organoid culture models aimed at identifying novel WNT-related signaling pathways during embryonic development, in stem cell niches that underpin tissue homeostasis and during cancer initiation and progression.
Submit a letter outlining your research interest, a CV and the names and addresses of three individuals who can serve as references to the mail addresses given below:
The iHuman Institute
ShanghaiTech University, 100 Haike Road, Pudong, Shanghai 200031, China
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