PhD Thesis Topic: Exploring the Neurobiology of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

5 Mar 2024
Job Information

Organisation/Company

Université Laval

Research Field

Chemistry » Biochemistry
Psychological sciences » Psychology

Researcher Profile

Recognised Researcher (R2)
Leading Researcher (R4)
First Stage Researcher (R1)
Established Researcher (R3)

Country

Canada

Application Deadline

30 Apr 2024 - 22:00 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Offer Starting Date

1 Sep 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Project overview:

An early clinical feature of ALS is an imbalance in energy homeostasis, which leads to an overall energy deficit. Due to the high energy demands and impaired glucose metabolism that occurs in ALS, there is a metabolic switch from glucose to lipids for energy production in the central nervous system. The successful candidate will lead a project investigating the cause and impact of this metabolic switch in the brain and spinal cord using animal models and cell-culture models of ALS/FTD. Utilizing methods like immunohistochemistry, confocal microscopy, neuron-glia co-cultures, western blotting and lipid and protein mass-spectrometry, the project aims to elucidate how the central nervous system manages lipids as an energy source and whether it is impaired in familial models of ALS, contributing further to the pathogenesis of disease. Find out more on our webpage: https://www.sephtonlab.ca/

 

Funding category: Contrat doctoral

PHD title: Doctorat de neurobiologie
PHD Country: Canada

Requirements
Specific Requirements

Requirements:

MSc in Neuroscience or a related field with evidence of expertise and productivity
Proficiency in one or more of the following: primary cell-culture, immunohistochemistry, western blotting, confocal microscopy, animal handling and data analysis.
Independence in research, creative problem-solving skills, and a collaborative mindset.
Strong communication skills in English and the ability to work effectively within a team.

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

Université Laval

Country

Canada

City

Quebec

Geofield

Where to apply

Website

https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/120851

Contact

Website

https://www.ulaval.ca/en/future-students/graduate-studies

STATUS: EXPIRED