Postdoctoral Position on “Combinatorial, High-Throughput Organoid Screens for Personalized Medicine”
Recent years have seen a surge in the development of microfluidicplatforms for a wide diversity of applications, from diagnostics to newfundamental science studies. Microdroplet-based platforms (a particular branchof microfluidics capable of generating and manipulating identical, fL tonL-sized droplets at kHz rates) has spearheaded several revolutionaryHigh-Throughput Screening (HTS) assays, notably for applications in single cellomics. Yet, other promising HTS applications of droplet-based microfluidics(such as drug screening) remain largely untapped due to the impossibility ofcurrent droplet generation strategies to handle drug libraries in acombinatorial manner.
The first phase of this project aims to develop astrategy to solve the aforementioned limitation of droplet-based technology bydeveloping a hybrid microfluidic-liquid handling platform with the capacity ofgenerating large droplet libraries with distinct chemical payloads. Your taskswill involve:
- Designing, manufacturing and testing of novelmicrofluidic devices capable of rapid and multiplexed droplet formation.
- Testing and applying amelioration strategies forstable long-term droplet storage and prevention of payload leakage / dropletcross-talk.
- Setting up and operation of droplet screeningsystems and lab automation devices (e.g. liquid handling systems).
In the second phase of this project you will adaptthis platform to enable the production of/experimentation with patient-derivedorganoids, with the aim of screening and selecting optimal combinatorialtreatments for Cystic Fibrosis (CF) patients not eligible for registeredmodulator treatments (which currently comprise10% of the ofthe total population of CF patients)
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