Postdoc position to study how xenotransplanted human cortical neurons can contribute to brain repair

Updated: 3 months ago
Job Type: FullTime
Deadline: 01 Jan 2021

<p class="text-justify">The Vanderhaeghen Lab (Stem Cell and Developmental Neurobiology Lab <a href="https://pvdhlab.org/" target="_blank">">https://pvdhlab.org</a> ) at the VIB-KU Leuven Center for Brain & Disease Research (<a href="http://cbd.vib.be/" target="_blank">">http://cbd.vib.be</a> ), is seeking a creative postdoctoral scientist to study the development and function of human cortical neurons transplanted in the mouse brain following cortical injury.<br></p>
<h2>Job description</h2>
<p>This highly multidisciplinary project will combine cutting-edge approaches including human pluripotent stem cell technology, mouse brain transplantation in models of injury, and cellular and functional analyses of the transplanted neurons and host circuits. </p>
<p>This project builds up on previous work of the host laboratory (<em>Linaro Neuron 2019; Espuny-Camacho Cell Reports 2018; Michelsen Neuron 2015</em>) to explore in an innovative way the rational design of brain repair targeting the neocortex. It will be undertaken in active collaboration with the Vision-to-Action Laboratory (Vincent Bonin, PI) at Neuro-Electronics Research Flanders in Leuven, Belgium, (NERF, <a href="http://www.nerf.be/" target="_blank">">www.nerf.be</a> ).</p>
<p><strong>Selected references from the host lab.</strong></p>
<p>Iwata et al.<em>Science</em> (2020) 369: 858-862.&nbsp;</p>
<p>Linaro et al. <em>Neuron</em> (2019) 104: 972–986.</p>
<p>Espuny-Camacho et al., <em>Cell Reports</em> (2018) 23:2732-2743. </p>
<p>Espuny-Camacho et al., <em>Neuron</em> (2017) 93:1066-1081. </p>
<p>Michelsen et al., <em>Neuron </em>(2015) 85:982-97<em>.</em></p>
<h2>Profile</h2>
<ul><li>We are seeking highly motivated individuals with a strong expertise and interest in neuronal development, circuit function and/or assembly, and experimental models of brain repair.</li><li>PhD in neuroscience, biology or related field.</li><li>Strong experience in neuronal cell biology, brain transplantation, or methods to investigate cortical circuit function are required. </li><li>Creative, enthusiastic, critically thinking, enjoying teamwork and excellent oral and written communication skills in English.</li><li>Molecular biology, systems, cognitive or behavioral neuroscience experience are a plus but not a requirement.</li></ul>
<h2>We offer</h2>
<ul> <li>A versatile and challenging academic position with very diverse contacts in a world-class research environment operating at an international level, and various opportunities to broaden your expertise
</li><li>A competitive compensation package based on expertise and experience
</li></ul><p><strong>Starting Date: as soon as possible</strong></p>
<h2>How to apply?</h2>
<p>For more information contact: Pierre Vanderhaeghen,&nbsp;<a href="mailto:pierre.vanderhaeghen@kuleuven.vib.be" target="_blank" style="background-color: rgb(255, 255, 255);">pierre.vanderhaeghen@kuleuven.vib.be </a>.</p>
<p class="text-justify">Please complete the online application procedure and include a detailed CV incl. list of publications, a motivation letter, and the contact information of three referees.</p>


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