Postdoc position on the role of heterozygous loss of ribosomal proteins RPL5 and RPL11 in cancer

Updated: 23 days ago
Deadline: 31 Jan 2020

(ref. BAP-2020-15)

Laatst aangepast : 7/01/2020

The laboratory for Disease Mechanisms in Cancer (KU Leuven, Belgium, www.LDMC.be) is looking for a motivated postdoctoral researcher. Our team played a pioneer role in the identification of acquired mutations in ribosomal proteins in cancer. To understand how mutations in this essential cellular machinery promote tumorigenesis, we characterize the impact of ribosomal protein mutations on the spectrum of expressed proteins in cancer cells (cellular translatome). In the past, our work mainly focused on the role for the ribosomal RPL10 R98S point mutation that is implicated in leukemia. Ribosomal proteins RPL5 and RPL11 are heterozygously lost in 10-35% of various cancer types. In this project, the downstream consequences of such a heterozygous loss of RPL5 and RPL11 in cancer cells will be studied in breast cancer and glioblastoma cell culture and mouse models using proteome and phospho-proteome based methodologies.


Responsibilities

The successful candidate will continue an ongoing research line in the lab to characterize the role of heterozygous loss of ribosomal proteins RPL5 and RPL11 in cancer. He/ she will perform proteomics screenings and biochemical experiments in cell culture and mouse models to identify the cancer promoting downstream consequences of RPL5/RPL11 loss. The successful applicant will also help in supervising PhD students in the lab and will be involved in writing of scientific papers, project reports and grant applications.


Profile
  • You obtained a PhD within the last 5 years or are close to obtaining a PhD in a relevant discipline.
  • You have a strong publication record.
  • You have a background in cancer biology and/or molecular biology.
  • Experience in working with mouse models and mammalian cell cultures as well as with standard molecular biology techniques is a strict requirement (transfection, transduction, PCR, western blotting, immunoprecipitation, cloning,…). Having a valid FELASA B certificate is a plus.
  • Experience with multicolor flow cytometry, in applying CRISPR-Cas9 technology, in protein based methodologies and in performing and analyzing proteomics experiments is a plus.
  • Apart from being a true team player, the candidate is expected to exhibit a high degree of independence, to have a problem-solving attitude and have strong analytical and technical abilities in addition to excellent communication and presentation skills.
  • You are fluent in English, both written and spoken.

Offer
  • An exciting job in a friendly and dynamic lab.
  • A stimulating and supportive international research environment at KU Leuven, an international top research institute.
  • Excellent training opportunities to broaden your technical and academic career skills.
  • 1-year postdoctoral position with possibility of extension for at least 2.5 more years provided a positive evaluation. The successful candidate will also be encouraged and will get full support to obtain independent fellowships (Marie-Curie, EMBO, or national funding organizations).
  • Our lab is situated in Leuven, a charming and vibrant university city that is only a 20 minutes train ride away from the city of Brussels, at the heart of Europe.

Starting date: To be negotiated. Any date after February 1st 2020.


Interested?

For more information please contact Prof. dr. Kim De Keersmaecker, tel.: +32 16 37 31 67, mail: [email protected]


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