There is an unmet need for successful neurorepair in aged patients and therefore, for innovations in therapies. We use the African turquoise killifish (Nothobranchius furzeri), the shortest-living vertebrate laboratory species that displays all cellular and molecular aging hallmarks characteristic to humans, as a model for in-depth investigations into brain aging. Recently, we have discovered that although young killifish are capable of full-blown neurorecovery upon injury, aged killifish lose these abilities. Aged killifish rather mimic the restricted repair capacities of (aged) mammalian brains, including chronic inflammation and glial scarring. In addition, we show a change in the number, morphology and the gene expression of progenitor cells (PCs) in the telencephalon due to aging, indicating a change in the cellular composition of the telencephalon, possibly linked to changes in cell state concerning the potency/failure for full-blown neuro-regeneration upon age. Our research group aims to extract new rejuvenation strategies from the killifish by reversing this aging-induced low repair capacity and to reinstate the high neuroregenerative abilities seen in young adult killifish. In this project, we aim to primarily focus on characterizing the progenitors and the true astroglia in the killifish.
Van Houcke J, Mariën V, Zandecki C, ..., Ayana R, ... & Arckens, L. (2021). Aging impairs the essential contributions of non‐glial progenitors to neurorepair in the dorsal telencephalon of the Killifish Nothobranchius furzeri. Aging cell (2021), 20(9), e13464.
Ayana, R, Zandecki, C., Mariën, V., Seuntjens, E., & Arckens, L. Single-cell sequencing of the adult killifish (N.furzeri) brain identifies an atypical progenitor, glial and neuronal heterogeneity. bioRxiv (2021)
Ph D Position (M/W/D), E13/65 % , Technical University of Munich, Germany, about 9 hours ago
01.06.2022, Wissenschaftliches Personal We are looking for a scientist (PhD student, m/w/d) who shares our enthusiasm about human T cell engineering and to work on our new project entitled “CRISPR...
Ph D Position For H2020 Project Astrotech, BCAM - Basque Center for Applied Mathematics, Spain, about 22 hours ago
The past four decades demonstrated that non-neuronal cells, called astrocytes are emerging as crucial players for brain function & dysfunction. A major obstacle of previous and current initiatives...
Ph D Student For Moons And Farrow Lab, VIB, Belgium, about 15 hours ago
Intraneuronal resource allocation: a key for functional circuit restoration in the central nervous system Research team This Ph.D. project runs within a joint effort from two internationally recog...
Ph D Student Position In Brassinosteroid Hormone Transport, VIB, Belgium, about 15 hours ago
Job description A major group of steroidal phytohormones, called brassinosteroids (BRs), is indispensable for plant growth and development. BRs are synthesized in the cell interior, but, unlike ma...
Ph D Position (M/F/D), Leibniz, Germany, 2 days ago
The Leibniz Institute of Virology (LIV), is committed to research on the biology of different human viruses as well as the pathogenesis of viral diseases. The Institute offers the opportunity to p...
Ph D Position: Bottom Up Reconstruction Of A Self Dividing Artificial Cell Using Microfluidics, Katholieke Universiteit Leuven, Belgium, about 17 hours ago
What distinguishes a living organism from a simple mixture of chemical reactions? It is generally agreed that a living organism needs to satisfy a basic set of conditions: compartmentalize its com...