We use complementary genetic and epigenetic approaches in mouse models, in order to discover genetic variants in noncoding regions of the genome underlying the etiologies of Tet1-dependent neurulation disorders, or the epigenetic dysregulation related to non-genetic factors, or the combination of both. Studies using transgenic mouse strains generated in the laboratory will be complemented with in vitro studies using mouse and human pluripotent stem cell cultures. Bulk and single-cell multiomics approaches will be used to investigate epigenetic mechanisms regulating chromatin accessibility, gene expression and DNA methylation in neurulation and cell fate reprogramming.
Luo X, van der Veer BK, Sun L, Bartoccetti M, Boretto M, Vankelecom H, Khoueiry R. Koh KP (2020). Coordination of germ-layer lineage choice by TET1 during primed pluripotency. Genes & Development 34(7-8), 598-618.
Bartoccetti M, van der Veer BK, Luo X, Khoueiry R, She P, Bajaj M, Xu J, Janiszewski A, Thienpont B, Pasque V and Koh KP (2020). Regulatory dynamics of Tet1 and Oct4 resolve stages of global DNA demethylation and transcriptomic changes in pluripotency. Cell Reports 30(7), 2150-2169.
Khoueiry R, Sohni A, Thienpont B, Luo XL, Vande Velde J, Bartoccetti M, Boeck B, Zwijsen A, Rao A, Lambrechts D, Koh KP (2017). Lineage-specific functions of TET1 in the post-implantation mouse embryo. Nature Genetics 49, 1061-1072.
Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A (2011). Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell 8, 200-213.
Postdoctoral Position In Brain And Cancer Immunology, VIB, Belgium, about 13 hours ago
Description The Movahedi lab and Van Ginderachter lab are looking for an outstanding postdoctoral scientist interested in understanding how the immune system, and in particular macrophages and den...
Doctoral Researcher (F/M/D), Leibniz, Germany, 1 day ago
The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI, www.leibniz-hki.de ) investigates the pathobiology of human-pathogenic fungi and ident...
Ph D Position In Neuroimmunology And Brain Macrophages, VIB, Belgium, about 13 hours ago
Description The Movahedi lab and Van Ginderachter lab are looking for an enthusiastic colleague to commence a Ph.D. in neuroimmunology and macrophage biology. The project is part of a high profile...
Ph D Studentship Fungal Infections, Trinity College Dublin, School of Medicine, Ireland, 19 days ago
Post Specification Post Title: PhD Studentship - Fungal Infections Department / School: Department of Clinical Microbiology, School of Medicine, Trinity College Dublin, the University of Dublin Lo...
Intercept Mds International Ph D Fellowships (# Of Pos: 12), Josep Carreras Leukaemia Research Institute (IJC), Europe, 13 days ago
The Innovative Training Network (ITN) “INTERCEPT-MDS - Exploring cell-to-cell heterogeneity and exploiting epigenetic regulation for the interception of myeloid disease cells" is recruiting 12 hig...
Ph D Student (M/F/D), Leibniz, Germany, 1 day ago
The Bernhard Nocht Institute for Tropical Medicine (www.bnitm.de ) is the largest Research Institute for Tropical Medicine in Germany and is the National Reference Centre for Tropical Pathogens, a...