Since over 25 years the Laboratory for Therapeutic and Diagnostic Antibodies focusses on the generation and characterization of monoclonal antibodies (mAbs), antibody derivatives, nanobodies and diabodies and application as either therapeutics, diagnostics or research tools. The current position is to strengthen our research related to nanobody discovery and development. The candidate will be exposed to a multitude of aspects of this research: immunization strategies, cloning of nanobody libraries, phage display, biochemical (AlphaScreen, ELISA, …) and cell based (FACS, reporter assays, …) screening techniques, protein expression in different host systems (E.coli, yeast, mammalian cells, …), protein purification, assay development, in vitro and in vivo characterization, nanobody engineering (affinity maturation, sequence optimization, protein fusions,…), etc. Potential research domains are related to innovative methods to improve antibody-drug conjugates (ADCs) for cancer therapy, developing novel high throughput nanobody/antibody screening methods, exploring new ways to deliver biologics over the blood-brain barrier, target & drug discovery in Alzheimer’s disease, … The exact project will be defined depending on the candidate’s interest and laboratory’s needs.
Postdoctoral Position In Nanobody Discovery, Max Planck Institute of Molecular Cell Biology and Genetics, Germany, about 18 hours ago
Background: Binders, such as antibodies, are indispensable research tools for the detection and manipulation of proteins, yet antibodies with the desired specificity and affinity are often not ava...
Ph D Student In Biochemistry / Biophysics / Structural Biology (M/F/D), Max Planck Institute of Molecular Cell Biology and Genetics, Germany, about 18 hours ago
International Max Planck Research School for Cell, Developmental, and Systems Biology (IMPRS-CellDevoSys) The IMPRS-CellDevoSys is an internationally renowned PhD Program that trains the future l...
Postdoc Position Mechanobiology Of Bioengineered Bone Organoids , ETH Zurich, Switzerland, about 5 hours ago
In der aktuellen Covid-19 Situation laufen die Rekrutierungen weiter. Es kann dabei allerdings zu Verzögerungen kommen. Vielen Dank für Ihr Verständnis. 100%, Zurich, fixed-term The Laboratory for...
Postdoctoral Studies In Dna Damage And Ubiquitin Signaling (Scholarship), Karolinska Institutet, Sweden, about 22 hours ago
Do you want to contribute to top quality medical research? The Department of Cell and Molecular Biology (CMB, https://ki.se/en/cmb/department-of-cell-and-molecular-biology) is one of five departme...
Ph D Position In Human Neuroimmunology , ETH Zurich, Switzerland, 10 days ago
In der aktuellen Covid-19 Situation laufen die Rekrutierungen weiter. Es kann dabei allerdings zu Verzögerungen kommen. Vielen Dank für Ihr Verständnis. 100%, Zurich, fixed-term The mission of the...
Postdoctoral Cryo Em Position For The Study Of Redox Relay Signaling Complexes, VIB, Belgium, about 18 hours ago
Position A postdoctoral research position is immediately available for structure-function studies of proteins involved in redox signaling. Successful candidates will join the exciting research env...