PhD in Molecular Microbiology

(ref. BAP-2022-875)

Laatst aangepast : 9/12/2022

Embedded within the KU Leuven (University of Leuven), the Centre of Microbial and Plant genetics is located on the Campus Arenberg (Heverlee). Within this Centre, the Michiels lab is focusing on unravelling the molecular mechanisms of antibiotic tolerance or persistence in bacteria. Although persisters are not genetically resistant, these cells are refractory to the killing action of antibiotics. Persisters are an important but neglected clinical concern as they underlie antimicrobial therapy failure and recurrence of chronic infections. The lab consists of 20 junior lab researchers and is seeking a dynamic and highly motivated PhD student.

Project

You will analyse the molecular pathways underlying bacterial persistence in Escherichia coli. The work involves genetic, omics (genome sequencing, transcriptomics), bioinformatics and single-cell (microscopy, microfluidics, FACS) analyses of E. coli bacteria in fluctuating antibiotic regimens.

In collaboration with the candidate, a detailed research plan will be drafted that will entail one or more of the following topics:

• Investigate the role of aggregates in persistence in both in vitro and in vivo setups. Zoom in on the composition and structure of aggregates and the involvement of disaggregation in persister resuscitation
• Unravel molecular mechanisms underlying persistence caused by new persister genes that were previously identified in a genome-wide association study performed in our lab
• Investigate the evolution of persistence and its relation with development of resistance

Profile

• The candidate holds a Master degree in bioengineering science, (bio)chemistry, (molecular) biology or biotechnology with the equivalent of at least distinction (15/20 on the Belgian scale). Master students expected to graduate in the summer of 2023 are also eligible
• The candidate has a critical and creative mind
• The candidate is a true problem solver with a proficiency to overcome technical challenges
• The candidate is a team player with good communication skills
• Proficient use of the English language for both oral and written communication
• Computational background is a plus

Offer

• A full-time PhD position for one year; after a positive evaluation, the contract can be extended to three additional years (four years in total)
• A working climate where trust, (international) collaboration, and commitment are essential
• An excellent young, stimulating and supportive international research environment
• High level scientific training at a top-ranked university; training in academic, thematic and soft skills.
• Access to state-of-the art tools and infrastructure

Interested?

For more information please contact Dr. Natalie Verstraeten, mail: [email protected] 

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