The Mechanobiology and Soft Matter group led by Prof Sylvain Gabriele at the University of Mons (Belgium) has an opening for a PhD student in the area of cell biophysics1-3 . The project falls with the group’s focus on understanding how mechanical cues from the matrix influence the structure and function of epithelial cells. In collaboration with the Hannezo’s group (IST, Austria), we have recently shown that the substrate curvature leads to thickness modulation of the epithelial monolayer and affects significantly nuclear shape and function4 . We believe that these findings open new avenues for studying how mechanical and chemical signaling at the cellular and multicellular level can be modulated by the physico-chemical properties of the matrix (i.e. stiffness, curvature, etc.). The goal of this research project is to study how the long-distance transmission of signal-regulated kinase (ERK) waves can be regulated by the matrix curvature by combining our recent findings4 and the collaborative works of Hannezo and Hirashima (Kyoto University, Japan)5,6 groups.
This project will be conducted in a highly interdisciplinary environment and will involved extensive collaborations with the Hirashima’s group (experimental aspects) and Hannezo’s group (theoretical aspects).
1- D. Mohammed et al. Innovative tools for mechanobiology: unraveling outside-in and inside-out mechanotransduction Frontiers in Bioengineering and Biotechnology 7, 162 (2019)
2- D. Mohammed et al. Substrate area confinement is a key determinant of cell velocity in collective migration Nature Physics 15, 858-866 (2019)
3- M. Versaevel et al. Collective migration during a gap closure in a two-dimensional haptotactic model Scientific Reports 11, 1-11 (2021)
4- M. Luciano et al. Large-scale curvature sensing by epithelial monolayers depends on active cell mechanics and nuclear mechanoadaptation BioRxiv https://www.biorxiv.org/content/10.1101/2020.07.04.187468v1
5- D. Boocok et al. Theory of mechanochemical patterning and optimal migration in cell monolayers Nature Physics 17, 267-274 (2021)
6- N. Hino et al. ERK-mediated mechanochemical waves direct collective cell polarization Developmental Cell 53, 646-660 (2020)
We are looking for a motivated, curious and autonomous candidate, eager to work in an interdisciplinary environment to perform a PhD in physico-chemistry for life sciences and cell biophysics. The ideal candidate would have an experimental training in cell biophysics and/or bioengineering, with experience in microfabrication techniques and cell culture. Experience in soft matter physics, image and data analysis is also desirable.
- The position is secured for 4 years and granted by the EPIFORCE project of the National Fund for Fundamental Research (F.R.S-FNRS)
- The salary is approximately 2000 €/month (must be defined based on the candidate’s CV)
- Preferred start date: 1st July 2021
- For inquiries, please contact Sylvain Gabriele: firstname.lastname@example.org
- Lab website: http://www.umons.ac.be/influx/sgabriele
Interdisciplinary Ph D Position In Quantitative Cell Biology And Biochemistry, University of Groningen, Netherlands, about 2 hours ago
We are looking for a highly motivated and enthusiastic PhD candidate with a strong background in cell biology, (bio)chemistry, (bio)physics or closely related fields to join the Cell Cycle Dynamic...
Ph D Fellowship In Cardiovascular Medicine, Katholieke Universiteit Leuven, Belgium, about 1 hour ago
Cell-cell interactions and the role of tissue microarchitecture in cardiac arrhythmias after myocardial infarction Cardiac myocytes in the MI border zone remodel in a highly specific manner predis...
Ph D On Electrokinetically Driven Microchips For Immuno Engineering, Eindhoven University of Technology (TU/e), Netherlands, about 9 hours ago
At the Department of Biomedical Engineering at Eindhoven University of Technology (TU/e), we currently have a vacancy for a postdoc in the field of microfluidics. To investigate the crosstalk betw...
Ph D / Post Doc In Biophysics , Technical University of Munich, Germany, about 4 hours ago
03.05.2021, Wissenschaftliches Personal Living cells rely on the ability of the cytoskeleton to continuously form and destroy diverse structures, which is strongly coupled to the adhesion processe...
Postdoc Position: Impact Of Anesthetics On Bone Sarcoma Metastasis , University of Zurich, Switzerland, about 9 hours ago
Sarcoma and Anesthetics Research Department, Balgrist University Hospital Postdoc Position: Impact of anesthetics on bone sarcoma metastasis 80-100 % We are looking for a dynamic, highly motivated ...
Ph D Position In Developmental Biology (1.0 Fte), Utrecht University, Netherlands, about 10 hours ago
We are looking for a highly motivated PhD student who will join our research efforts to understand how epithelial cells become polarized, functionally specialize, and function. Cell polarity – the...