Doctoral fellow - Department of Biomolecular Medicine

Last application date Oct 31, 2021 00:00

Department GE31 - Department of Biomolecular Medicine

Contract Limited duration

Degree Master

Occupancy rate 100%

Vacancy type Research staff

Bioinformatics Doctoral Fellow Position at Ghent University, Belgium

The Ntziachristos laboratory studies the mechanistic aspects of oncogenesis with an emphasis on posttranslational and epigenetic regulation in acute leukemia. We focus on how oncogenes interact with each other and with epigenetic modulators to influence gene expression programs as well as how their function is related to tri-dimensional (3D) structure of the nucleus and other biological aspects of cancer cells. Recent studies from our group focus on how active deubiquitination controls aspects of oncogenesis, including transcription factors or splicing, and ultimately leads to drug resistance in leukemia. To address these questions, we use high-throughput molecular and cell biology techniques like RNA-Seq, ChIP-Seq, 4C-Seq and HiC, fluorescent in situ hybridization, biochemical analysis e.t.c., in cell lines and primary cells of human origin and tissues of mouse models of disease. In addition to understanding cancer biology these findings help us design and test targeted therapies in preclinical models of leukemia. Our research is currently supported by the Research Foundation Flanders (FWO), via a generous Odysseus Grant, and by UGent start-up funds.
Highly-motivated and collaborative scientists, that hold a Bachelor degree, and with a strong track record and expertise in Bioinformatics, with a focus on RNA biology and the analysis of splicing phenomena, computational systems biology or related fields are encouraged to apply. The candidates should preferably have knowledge of gene expression biology and of high-throughput methodologies such as RNA-Seq, ChIP-Seq, HiC, and 4C-Seq. Successful candidates will be part of a multidisciplinary team and will be part of projects sought out to understand oncogenic function in leukemia.
The group is a member of the Faculty of Medicine and Health Sciences and the Department of Biomolecular Medicine situated in the campus of Ghent University, in the heart of the Ghent metropolitan area. The team has access to cutting-edge technology and facilities and is exposed to the vibrant scientific community of Ghent University, the Flemish Institute for Biotechnology (VIB) and other research centers in Belgium. Scientists in the group have the opportunity to present their work and get feedback in Institutional, National and International forums.
The appointment offers competitive salary and generous benefits and the position can be initiated effective immediately.
Related links:
https://www.ntziachristoslab.com/
https://www.ncbi.nlm.nih.gov/pubmed/?term=ntziachristos+p
https://www.fwo.be/media/1024349/results-odysseusprogramme-2020.pdf
https://www.ugent.be/ge/biomolecular-medicine/en

Applicants should contact Panos Ntziachristos, [email protected] , or [email protected]  with their CV and short motivation letter.