This PhD project is part of the PhD Program Cellular Basis of Diseases (CBD) (https://phd-cbdiseases.i-med.ac.at/ ) at the Medical University of Innsbruck, Austria. The PhD program offers 15 fully funded PhD positions. The interdisciplinary PhD projects address the molecular control of metabolism & inflammation and connect basic life science and computational biology with medicine. The Medical University of Innsbruck is one of the largest facilities that connects basic - and clinical research in Austria. The range of studies covers human medicine and molecular medicine and offers access to state-of-the-art research and core facilities. In addition, the location in the ‚Heart of the Alps‘ offers an international flair and a wide range of outdoors activities with a high quality standard of living.
It is our overall goal to provide control of metabolism and inflammation on the molecular, intra- and intercellular level in health and disease.
Project 5: The interplay between innate immunity and cholesterol metabolism in the liver
The Question: The interaction of liver-resident macrophages (Kupffer cells) with hepatocytes is essential to maintain liver homeostasis. Our findings suggest a tight cholesterol-regulating cell-to-cell interaction between liver-resident Kupffer cells and hepatocytes (Demetz E et al., Eur Heart J. 2020). How this intercellular interaction regulates the quantity of circulating low-density lipoprotein cholesterol (LDL-C) during severe inflammation or upon depletion by Kupffer cell-directed chemotherapy is unclear.
The Goal is to gain molecular understanding on how Kupffer cells control LDL-C uptake in hyperlipidemia and atherosclerosis and to investigate if and how hepatic Kupffer cell numbers are regulated upon cholesterol accumulation.
Ph D Student, Ghent University, Belgium, about 15 hours ago
Job description The research group of Tom Taghon (https://www.taghonlab.ugent.be ), located in Ghent, Belgium, is looking for a talented and highly motivated PhD student to join our team. Researc...
Fachbereich Biologie, Chemie, Pharmazie Institut Für Chemie Und Biochemie Musculoskeletal Development And Regeneration Group Ph D Student (M/F/D) 65% Part Time Job Limited To 3 Years Entgeltgruppe 13 Tv L Fu Refence Code: Adipo 2020 Bewerbungsende: 26.10.2020, Free University of Berlin, Germany, about 7 hours ago
A PhD student position is available in the Musculoskeletal Development and Regeneration Lab (https://www.bcp.fu-berlin.de/en/chemie/biochemie/research-groups/stricker-group/index.html) at the Inst...
Ph D Position: Nanoparticle Based Tracking Tools For Stem Cell Imaging, Maastricht University, Netherlands, 8 days ago
PhD position: nanoparticle based tracking tools for stem cell imaging PhD position: nanoparticle based tracking tools for stem cell imaging Published Deadline Location 9 Oct 25 Oct Maastricht PhD ...
Ph D Scholarship In Mapping Of Cd8 T Cell Recognition To Sars Cov 2 And The Role Of T Cell Cross Recognition, Technical University of Denmark, Denmark, about 14 hours ago
A PhD position is available in the Section of Experimental and Translational Immunology (xTI), Dept. of Health Technology, at the Technical University of Denmark (DTU). In the Section ofExperiment...
Ph D Position In Stem Cell And Developmental Epigenetics, Katholieke Universiteit Leuven, Belgium, about 20 hours ago
We use complementary genetic and epigenetic approaches in mouse models, in order to discover genetic variants in noncoding regions of the genome underlying the etiologies of Tet1-dependent neurula...
Ph D Student Position In The Research Group Of Dr. Xingqi Chen , Uppsala University, Netherlands, about 23 hours ago
Published: 2020-10-21 Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to ...