prae doc (PhD position) Cellular Basis of Diseases

Updated: about 1 month ago
Job Type: FullTime
Deadline: 30 Sep 2020

This PhD project is part of the PhD Program Cellular Basis of Diseases (CBD) (https://phd-cbdiseases.i-med.ac.at/ ) at the Medical University of Innsbruck, Austria. The PhD program offers 15 fully funded PhD positions. The interdisciplinary PhD projects address the molecular control of metabolism & inflammation and connect basic life science and computational biology with medicine. The Medical University of Innsbruck is one of the largest facilities that connects basic - and clinical research in Austria. The range of studies covers human medicine and molecular medicine and offers access to state-of-the-art research and core facilities. In addition, the location in the ‚Heart of the Alps‘ offers an international flair and a wide range of outdoors activities with a high quality standard of living.

It is our overall goal to provide control of metabolism and inflammation on the molecular, intra- and intercellular level in health and disease.

Project 5: The interplay between innate immunity and cholesterol metabolism in the liver

The Question: The interaction of liver-resident macrophages (Kupffer cells) with hepatocytes is essential to maintain liver homeostasis. Our findings suggest a tight cholesterol-regulating cell-to-cell interaction between liver-resident Kupffer cells and hepatocytes (Demetz E et al., Eur Heart J. 2020). How this intercellular interaction regulates the quantity of circulating low-density lipoprotein cholesterol (LDL-C) during severe inflammation or upon depletion by Kupffer cell-directed chemotherapy is unclear.

The Goal is to gain molecular understanding on how Kupffer cells control LDL-C uptake in hyperlipidemia and atherosclerosis and to investigate if and how hepatic Kupffer cell numbers are regulated upon cholesterol accumulation.


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