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Field
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Assessment and non-animal methods (NAMs). We combine in vitro molecular biology, mass-spectrometry-based proteomics, bioinformatics, evidence synthesis and computational modelling to understand how
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of cultivated and wild through multifaceted, modern techniques (genomic, expression analyses, proteomics, metabalomics, etc). This project aims to use these techniques to understand stress response and resistance
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, in addition to genetic essentiality and proteomic workflows. The appointed researcher will be required to drive their own experimental investigations, and contribute to wider research efforts in
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and organoid platforms, genome engineering technologies, advanced microscopy, spectral flow cytometry, single-cell and spatial genomics, proteomics and biomarker laboratories, and high-performance
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, including genomic, transcriptomic, epigenomic, proteomic, metabolomic, and circulating biomarker data derived from patient tissues and liquid biopsies. Our goal is to characterize the molecular processes
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expertise in biochemical, biophysical, cellular, structural, and/or proteomic approaches to study target engagement, target validation, molecular recognition, drug action, and protein–ligand interactions
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topics to work on: (1) In vitro assays to determine inhibitor efficacy against redox membrane proteins (2) Cysteine enrichment of DsbA substrates in E. coli and Mycobacteria using proteomics. (3) determine
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bioinformatics analysis pipelines for processing RNA-seq, single-cell RNA-seq, genomics and proteomics data. Develop novel algorithms and integrated data visualization applications when existing software packages
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samples, validated mouse models of hemorrhagic shock, a 3D endothelial flow model, and high-throughput proteomics, metabolomics, and lipidomics. Projects include therapeutic modulation of APC activity via
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conditions. In this role, you will be responsible for conducting in-depth proteomic analyses of ribosomes from a range of species, with a focus on their post-translational modifications. Novel post