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triazine-containing analogues of phenylalanine (Chem. Eur. J (2015) 21 14376) to generate new probe molecules for chemical proteomics and chemical biology. Dependent upon the particular target these might
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of Resveratrol and similar compounds on lifespan and ageing (senescence) markers in Killifish using RNA-seq and proteomic approaches. Once novel pathways are identified, the project will then use gene editing
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the powerful companion technology of chemical proteomics, we now envision the prospect of mapping biological coverage systematically in a native cellular context. In this project, we will develop
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and proteomic approaches. Once novel pathways are identified, the project will then use gene editing (CRISPR/Cas9) of Killifish to validate these novel mechanisms of senescence reversal. This project
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project will provide high-quality, specialised training in cutting edge omics (proteomics, lipidomics, transcriptomics), modern molecular biology techniques as well as training in various infection models
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will provide high-quality, specialised training in cutting edge omics (proteomics, lipidomics, transcriptomics), modern molecular biology techniques as well as cultivation of model organisms
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-of-the-art techniques in cell biology, genetics, molecular biology and proteomic, this project aims at characterizing a novel signalling pathway modulating root nodule symbiosis. The insights gained from
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pattern recognition receptor-cytokine responses to oral pathogens, leading to adopting a proteomic approach in the identification of therapeutic targets for resolution of chronic inflammatory mucosal
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, before changes in the lung occur. Excitingly microRNAs can also act as ongoing lung remodelling markers. Proteomic profiling of human pulmonary fibrosis and interstitial lung disease has also revealed a
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enables the study of entire bacterial membrane proteomes from the perspective of structure-based drug discovery. As part of this Cresset-sponsored PhD studentship (https://www.cresset-group.com), you will