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interrogate using innovative culture techniques, genetic manipulation and multi-omics analysis including proteomics and transcriptomics with a view to identifying novel therapeutic targets. You should have a
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: A proven track record of success in applying multidimensional FACS analysis, molecular biology and protein chemistry techniques to the study of protein folding homeostasis in the Endoplasmic Reticulum
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tissue and developmental context specific mechanisms and the underlying plant proteins to study the phenotypic consequences for plant microbe interactions and plant development. You will receive
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to measure RNA and protein expressions using single-cell and spatial technologies, with increased throughput and resolution. Our ultimate goal is to develop predictors of treatment response, early relapse and
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, construction of recombinant viruses and replicons, human intestinal organoid culture and infection assays, RNA/protein/organelle extraction and analysis, protein-protein and protein-RNA interaction assays
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development and applications of a microfluidic platform for analysing protein aggregation, with a focus on high-throughput data analysis and management, a project funded by the Michael J. Fox Foundation. The
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, Agrobacterium-mediated transient expression, and Arabidopsis thaliana transformation and husbandry. Proficiency in structural biology, plant developmental biology, synthetic biology, protein bioengineering
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instrumentation and computational methods for data analysis and apply them to solve and model and structures of biochemical and biomedical importance. The structures will be chosen and investigated to address
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comparative genomics and transcriptomics to investigate the role of codon usage in gene regulation. You will lead the generation and analysis of sequencing data and carry out downstream bioinformatic analyses
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aims to develop and apply the cutting edge of Bayesian analysis and machine learning to the optimisation of satellite configurations for GNSS-R. Combining the data science expertise of Dr Handley's