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of innate immunity. The results will be highly relevant to understanding the regulation of inflammation as well as the development of new therapeutic strategies to treat inflammatory disease. Summary
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controls almost every cellular process in humans, including targeting poorly folded proteins for destruction to prevent them harming the cell. When ubiquitin signalling goes wrong, many different disease
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, our incomplete understanding of the molecular mechanisms of stroke is severely hindering the ability to devise treatments that target the disease process that leads to stroke. Over the past decade
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and cellular mechanisms shaping spatial and temporal trajectories of liver regeneration and cancer. Linking computer simulations with experimental observations will further uncover intrinsic and
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. Peripheral vertebrate nerves show an amazing capability to regenerate, crossing scar tissue and following the guidance of Schwann cells in the process. By extending a hand-like structure, a growth cone that
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, within each N. perurans cell is an endosymbiotic kinetoplastid, named Perkinsela, on which it relies for essential metabolic processes [6, 7]. This is a secondary endosymbiosis that is unique among