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- Institute of Biochemistry and Biophysics Polish Academy of Sciences
- Łukasiewicz Research Network - Krakow Institute of Technology
- Mossakowski Medical Research Institute, Polish Academy of Sciences
- Institute of Bioorganic Chemistry Polish Academy of Sciences
- Institute of Molecular Physics, Polish Academy of Sciences
- Institute of Physical Chemistry, Polish Academy of Sciences
- Lodz University of Technology
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- Łukasiewicz Research Network – PORT Polish Center for Technology Development
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, proteins, metabolites), aided by in silico target prediction, will enable us to uncover putative target of the compound, which will then be validated functionally using a broad range of biochemical and
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responses to pharmacological DDK inhibition in order to identify predictive biomarkers of sensitivity and resistance and lay the groundwork for patient stratification strategies essential to clinical
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, in the transition between the two catalytic conformations of the spliceosome. Our current model predicts that direct interaction between the Prp8-RT beta-hairpin loop and the U2 sequence between helix
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describing the stability and functionality of bioactive ingredients under storage and application conditions, supporting the development of an AI prediction system, and preparing SOP/IFU documentation. ICP-OES
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these transitions – particularly the onset of synchronization – affect energy dissipation and energy flows between oscillators. The predictions of the mean-field theory will subsequently be validated
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Predictive, Preventive, Personalized, and Participatory (P4) approaches in health and medicine. Within the IRAP framework, the project’s scientific goal is to discover and validate novel therapeutic concepts