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-of-the art computational models, the approach to be developed in the thesis is expected to yield reproducible, explainable results, increasing the reliability of clinical decision-making and paving the way
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offer major advantages over inorganic systems, including well-defined structures, identifiable active sites, and detailed insight into catalytic mechanisms in homogeneous solution. In addition, ligand
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microbiology and structural biology; experimental design and execution; scientific literature research and data mining; molecular biology/genetic engineering (cloning, subcloning, mutagenesis, construction
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coalescence under thermomechanical loading using scanning electron microscopy (SEM) and X-ray microtomography. Ultimately, the validated virtual laboratory will provide reliable predictive indicators and
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focuses on the structural and dynamic characterization of intrinsically disordered and multidomain proteins involved in major biological processes, combining experimental biophysics approaches (SAXS, NMR
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pombe. We hypothesise that rapid adaptive responses involve post-translational modifications (PTMs) of cohesin, a complex essential for chromatin structuring. These PTMs could remodel chromatin
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of Clermont-Ferrand. This joint research unit (UMR) currently comprises 43 permanent researchers and a total of 102 staff members, including contract staff, PhD students and postdoctoral researchers. The LAPSCO
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remodelling events, thereby generating the mechanical forces required for its motility. This motility also relies on the dynamics of adhesion structures to the extracellular matrix. Genetic evidence
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- Knowledge of molecular biology techniques (DNA extraction, qPCR) - Rigorous and reliable - Initiative and creativity - Ability to work independently and organise experimental work effectively - Good oral and
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punctual mobilities within the partners of the project consortium. The PhD task will be dedicated to the 3D printing of nano-structured polymer materials by photo-Polymerization Induced Microphase Separation