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background, one or two of: Formal skeleton and composition — GearSpec as a contract $(Requires, Provides, State, Effects, Assumptions, Guarantees, Parameters)$; AppGraph as a typed attributed hypergraph; an
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generation of social, computer-based, and cyber-physical systems that make a substantial contribution to the welfare of our society, for example, via embodied intelligent systems that are tailored to users
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approaches that reduce the dimensionality of parameter spaces and produce mechanistically realistic, experimentally testable predictions. As a result, systems-oriented biological research is inherently
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