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Generation Sequencing (NGS, also known as Massively Parallel Sequencing) has revolutionized molecular genetic research and clinical diagnostics over the past decade. Appropriately scaled, this technology can
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, "Second-order nonlinear frequency conversion in InGaP-on-insulator waveguides," Opt. Lett. 50, 3652-3655 (2025), https://doi.org/10.1364/OL.555573 N. Nader et al., "Heterogeneously Integrated Distributed
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Advanced Single-Photon-Detector Technologies for Quantum Communications and Metrology NIST only participates in the February and August reviews. Quantum communication, the distribution of entangled
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these complex communities by developing sample preparation techniques that are compatible with NMR and mass spectrometry-based techniques. This will allow parallel multimodal analysis including proteomic
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less). To address this technological bottleneck, we are developing a new technology platform--next gen protein sequencing--based on large-scale, massively parallel, single-molecule peptide sequencing
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molecular motors and RNA-folding. In a parallel effort, we significantly enhanced the biophysical capabilities of an atomic force microscope (AFM). Specifically, we achieved sub-pN force precision and
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absorption fine structure), development of data-analysis approaches and computer software for simultaneous structural refinements using multiple types of data combined with ab initio theoretical modeling
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include broadband, on-wafer microwave measurements up to 220 GHz, nonlinear measurements of mixing products and intermodulation, thermo-reflectance measurements for mapping chip temperature distributions
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distribution of the monomers with the aforementioned analysis serving as validation. Proposals will focus on either the synthetic or computational approaches to these challenges but should address
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scaled up to handle large numbers of samples in massively parallel, low-cost analysis systems. Before such systems can be realized, the electromagnetic response of biochemical samples must be understood in