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leukaemia (ALL) experience premature frailty (age 44) defined by muscle atrophy. Muscle protein synthesis is crucial for muscle growth and relies on physical activity and dietary protein; however
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The GW4 BioMed3 Doctoral Landscape Programme is offering up to 18 MRC funded studentships across a range of biomedical disciplines, with a start date of October 2027. These four-year studentships provide funding for fees and stipend at the rate set by the UKRI, as well as other research training...
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eversion. Internal pressure will be measured directly in vivo and related to muscle activity and the dynamics of eversion. The mechanical properties of the tissues will also be measured to determine their
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using multi-Omics analysis, we found dysfunction of vascular endothelial cells interacting with smooth muscle cells leading to arterial medial calcification in chronic kidney disease. The Postdoctoral
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leading cause of heart failure and sudden cardiac death in young adults. While often caused by faults in heart muscle proteins, how these genetic changes lead to heart thickening, scarring and electrical
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kidney function and children with stage-5 CKD (before dialysis), to establish the cellular and molecular map of early paediatric vasculopathy (endothelial cells, smooth muscle cells, fibroblasts, immune
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the free energy released from ATP hydrolysis into mechanical work on actin filaments, thanks to allosteric communication between the active site and the force-generating subdomains. In muscle cells, myosins
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-synchronized stimulation system (rSynES), developed by Dr. Isabelle Vivodtzev, targets accessory respiratory muscles and has shown promising results in improving respiratory function. Suggesting that it may
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in a randomised, placebo-controlled design framework. Biological ageing is associated with a progressive decline in mitochondrial efficiency, NAD⁺ availability, skeletal muscle function, and
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complementary aims: Aim 1. To determine how massive gene loss has reshaped heart, axial muscle and neuromesodermal development in chordates, using single-cell omics, gene-expression analyses and functional