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transcript architectures and developmental gene regulation in mouse development. A major focus of the role will be the analysis and validation of novel transcript isoforms identified using long-read sequencing
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-genome sequencing. You will possess strong analytical, problem-solving, and data interpretation skills, with the ability to work both independently and collaboratively within a multidisciplinary research
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, including detailed project planning to coordinate multiple workstreams and meet deadlines across the human and mouse experimental programmes. Design and run human EEG studies in which participants perform
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& Human Flourishing, Stoke House, Oxford, OX3 9BX. You will lead a programme of research in the foundations of AI alignment for human flourishing.You will manage and monitor research resources and
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modelling, and machine learning approaches to analyse large-scale datasets, including bulk and single-cell sequencing, gene expression arrays, proteomics, and metabolomics. Working closely with senior
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, including RNA work, protein purification, mammalian cell culture, next generation sequencing genome-wide analyses (ChIP) and mass spectrometry. You will establish and optimise protocols, design and accurately
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within the Department. Experience of working collaboratively within multidisciplinary research teams is desirable. Experience in bioinformatics and the analysis of next-generation sequencing data would
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of new treatments including in vitro and in vivo proof-of-concept efficacy data. This is an opportunity to work across multiple disciplines spanning retinal biology, viral vector technology and
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sequencing, 10X Xenium spatial transcriptomics, multiplexed immunohistochemistry, calcium imaging and high-density multi-electrode array recordings to define how microglial states evolve after neuronal death
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, western blotting, qRT-PCR, IHC/immunofluorescence, FACS, bulk and sc-RNA-sequencing analysis is essential. You will have excellent communication skills, including the ability to write for publication