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research focuses on detecting genomic variation that occurs during long-term culture and manufacturing stress. Projects may involve using Next-Generation Sequencing (NGS) to map transgene integration sites
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informatics developers in the public-private-academic Genome in a Bottle Consortium to develop methods to integrate short-, linked-, and long-read sequencing technologies to form benchmarks for somatic variant
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of viral adventitious agents. Next-generation sequencing offers the potential for nontargeted detection and rapid turnaround time. The Applied Genetics Group is investigating potential standards and methods
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or exceptionally well characterized property with known uncertainties. New biological “’omics” measurements, particularly sequencing-based methods, can produce 103 to 109 values from biological systems
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generation DNA sequencing; evaluation and testing ontologies for describing and organizing biological and medical information; and languages for capturing bio-informatics analyses and computational processes
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301.975.5473 Description Molecular diagnostics are a crucial part of personalized medicine. Molecular diagnostic methods such as PCR, qPCR, RT-PCR and Next-Generation Sequencing (NGS) can be used to detect
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distinct species or strains, and currently only molecular methods (e.g. polymerase chain reaction, sequencing) are able to differentially enumerate microbes in such a mixture. However, measurement bias in
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independent strategies (metagenomics, bioinformatics, synthetic biology) to determine microbial function from sequence data. Since this project is highly interdisciplinary, we are seeking applicants from
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that the interaction between polymers and a single nanopore provides the physical basis of a multi-analyte sensor. Work is also underway to determine whether this system could be used as tool to rapidly sequence long
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. The Associate will utilize advanced measurement capabilities including LC-MS/MS, LC-HRMS, GCxGC-MS, ICP-OES, and NMR to develop methodologies for chemical contaminant profiling, or next-generation sequencing