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regenerative epithelial state that arises during lung repair, are co-opted by oncogenic KRAS to initiate lung cancer. The work combines inducible lineage-tracing mouse models, lung injury and tumor-initiation
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understanding the mechanisms that govern tissue regeneration in the alveolar region of the lung. The lab combines genome-wide ‘omics approaches, genetic mouse models, in vivo and ex vivo live imaging
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cellular mechanisms underlying these disorders using cell-based assays, blood vessel organoids, and zebrafish and mouse models, working alongside neurosurgeons, computational scientists, and clinical
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organoid culture, co–culture assays, rapid genomic editing tools, multi–allelic mouse models, mouse live imaging, establishment of new transplant models, drug treatments, collection of tissues and fluids
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, and microscopy development. In particular, and relevant to this position, we are interested in demonstrating the power of our imaging techniques for deep-tissue imaging of the mouse spinal cord
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focused on hematological malignancies, genetics, gene editing, and mouse models. Overview of the position: We are seeking a highly motivated postgraduate research associate interested in joining the
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gene variants already identified in human native and allograft kidney disease, to elucidating mechanisms via invitro tools to the development and/or application of unique mouse models for in vivo
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studies to study the long-term cardiovascular consequences of preeclampsia using mouse models to address this clinically relevant question. The laboratory is located in the Vascular Biology and
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mouse models, in vivo two-photon structural and functional imaging with calcium indicators, chemogenetics, viral and transgenic tools, behavior, and molecular profiling to link circuit activity to
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cytometry, mouse models Reproducible research practices (pipeline organization, documentation standards, figure generation, and publication) Exposure to directed evolution and the selection of hyper