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of the CCR4-NOT complex. This leads to enhanced mRNA decay, resulting in e.g. natural killer cell activation, or evasion of the immune system by cancer cells. The molecular details of how MEX3 proteins recruit
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understanding and an experimental background in protein biochemistry and molecular biology. Since the project is part of a large and active trans regional consortium (https://trr186.uni-heidelberg.de
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the goal to mechanistically understand and functionally inhibit critical palmitoylation events. Structural biology methods are readily available to the group and comprise NMR, X-Ray, EM and MS. A highly
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project that aims to investigate the molecular mechanisms involved in cross-membrane substrate translocation using a combination of experimental and computational techniques. The candidate will establish