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collaborative research combining functional models of acquired drug resistance with the clinical validation of novel circulating tumor DNA (ctDNA) assays. While the primary focus is wet lab experimentation
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-based perturbations, base/prime editing, and targeted epigenetic modulation). Functional genomics in neuronal systems, including transcriptomic and epigenomic profiling. Model systems such as human iPSC
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cellular biology approaches. The Park Lab develops human stem cell-based neural models to investigate molecular and cellular mechanisms regulating neurodevelopment and neural function, and to understand how
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aneurysms, cavernous malformations, and arteriovenous malformations, using patient cohorts and surgical specimens together with cellular and in vivo models. The successful candidate will study the molecular
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application of unique mouse models for in vivo pathway discovery and validation. Experience or interest in flow cytometric analyses, and basic immunological techniques will be essential and interest in
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stress affects specific cell types in the nervous system and the gut, using human pluripotent stem cell (hPSC)-derived models of the enteric nervous system. Our work sits at the intersection of stem cell
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-tracing mouse models, lung injury and tumor-initiation systems, single-nucleus multiome (RNA and ATAC) and spatial profiling, and validation in human early-stage lung adenocarcinoma specimens. The position
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the same genetic material generate markedly different cells, and how this information is encoded within the genome. We utilize stem cells and cancer model systems, though projects range across disciplines
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established internationally recognized experimental platforms for the study of intraerythrocytic parasites, parasite metabolism, chemical biology, and preclinical models for therapeutic discovery and
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problems in the field such as: how to identify new targets for cancer immunotherapy, and how to enable precise control of adaptive immune responses through engineered cellular and recombinant therapies