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activities will include: o Human Brain Modeling: Generating and maintaining patient-stratified iPSC lines and innovative 3D "brain chimeroid" models. o Advanced Neurophysiology: Assessing functional network
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Modeling: Generating and maintaining patient-stratified iPSC lines and innovative 3D "brain chimeroid" models. o Advanced Neurophysiology: Assessing functional network activity and synaptic dynamics using
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in the meninges of murine models of activated PI3Kδ syndrome (APDS), an inborn error of immunity associated with immune and neurodevelopmental abnormalities. In parallel, you will lead the
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disease-relevant cellular models of EBV-infected B cells, modulate ERAP2 activity, and read out the downstream consequences for antigen presentation, NK and CD8+ T cell cytotoxicity, and B cell survival