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technological platform that enables rapid vaccination against emerging pathogens. Despite the major successes seen in SARS-CoV-2 vaccination, current mRNA vaccines elicit CD8+ T cell responses that are less
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of the Bacterial Cell Wall Unit headed by Ivo G. Boneca. This is a collaborative project with the teams of Raquel Mejias-Luque of the Technical University of Munich and of Richard Ferrero of the Monash University
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to model HBV induced immune pathologies and have recently evaluated a direct acting antiviral in this context resulting in some functional cures (Fernandes et al. Cell Host & Microbe 2026). Project
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) that is imported and used by malaria parasites for lipid damage repair caused by oxidative stress during intra-erythrocytic parasite growth (Cell Reports (2022) 39(11):110923). PLA2 inhibitors that target
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responses induced in antigen presenting cells, and the differentiation of specific B and T cells will be evaluated by spectral flow cytometry and scRNAseq, while CD4+ T cell / B cell interactions will be
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collaborative teams, bridging the gap between cell biology, genomics and pathogenesis. With your expertise in cell biology (cell culture of human primary cells), you will characterize the mechanisms of host
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://research.pasteur.fr/fr/department/immunology/ ). The Guermonprez lab investigates the role of dendritic cell subsets in regulating T cell responses and explores novel immunotherapeutic approaches (https
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the interface of machine learning and biology, developing innovative machine learning methods for single-cell data analysis (tools developed by the team: https://github.com/cantinilab). Single-cell high
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; Jacob et al., Cell Stem Cell 2022; Di Carlo et al., Nature Immunology 2023). Building on these findings, we aim at identifying novel mechanisms regulating the tumor microenvironment and antitumor immunity
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perturbations), pharmacological interventions (senolytics and senomorphics), and organoid systems with functional assays, flow cytometry, advanced imaging, and high-dimensional approaches, including single-cell