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. Cell Division We study the biochemical logic that ensures high-fidelity chromosome segregation during mitosis. The key molecular components are known, but how they are assembled, regulated, and
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endoplasmic reticulum (ER) membrane. The project will combine cutting-edge approaches in functional genomics, mechanistic cell biology, cryo-electron microscopy, and protein engineering. We are particularly
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include: Identifying spatial determinants of therapeutic delivery and response in solid tumors, including antibodies, antibody-drug conjugates, immunotherapies, targeted therapies, and engineered cell
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at the time of application. Experience in molecular and cell biology techniques, preferably in single cell sorting (FACS), scRNA-seq, spatial transcriptomics and very strong multi-omic data analysis skills
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using in vivo Perturb-seq. This project is related to a new NIH-funded Program Project Grant aimed at identifying differences and similarities in gene function across vascular cell types and diseases, as
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Expertise in primary cell isolation and culture, FACS, confocal imaging, and mouse genetics is preferred Experience with transcriptomics and programming language suitable for computational analysis (e.g. R