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to discover molecular pathways showing opposite patterns across risk- and protective-variant human iPSC-derived microglia. The student will prioritise pathways, perturb candidate genes, and test whether
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as a key regulator of immune suppression in GBM, influencing lipid-laden macrophages and microglia, regulatory T-cell differentiation, cytotoxic T-cell exhaustion, and the wider balance between anti
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, astrocytes, and even microglia. Building on this work, we seek to harness the power of this new tool to optimize its therapeutic use for a wide variety of conditions including epilepsy, neuropsychiatric
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