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, maintenance and relapse of acute myeloid leukemia (AML). We use various models to dissect critical cellular and molecular mechanisms of AML initiation and maintenance (Stavropoulou et al. Cancer Cell, 2016
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mechanisms of AML initiation and maintenance (Stavropoulou et al. Cancer Cell, 2016; Lopez et al., Cancer Discovery, 2019, Forte et al., Cell Metabolism, 2020; Leonards et al., Nat Commun 2020, Piqué et al
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. student with a strong interest in conducting high level research in the fields of T-cell immunobiology and cancer immunotherapy. This position will be based in the Department of Biomedicine (https
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represents a central limitation to current anti-cancer immunotherapies and strategies aiming at reversing this process are still lacking. By exploring the intimate mechanisms regulating CD8 T cell exhaustion
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to assess chemical-induced alterations in glucocorticoid pre-receptor enzyme activity and regulation. Promoter-reporter cell lines will be generated for HSD11B1, converting inactive cortisone to the potent
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, CD8 T cell exhaustion represents a central limitation to current anti-cancer immunotherapies and strategies aiming at reversing this process are still lacking. By exploring the intimate mechanisms
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. Promoter-reporter cell lines will be generated for HSD11B1, converting inactive cortisone to the potent glucocorticoid cortisol, and HSD11B2, catalysing the reverse reaction. Enzyme activity assays
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into the mechanisms underlying the repair of injured tissues after various types of insults. Topics/approaches may include analysis of (i) the heterogeneity of injured/healing tissues and the corresponding healing
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this process are still lacking. By exploring the intimate mechanisms regulating CD8 T cell exhaustion, our group aims to identify innovative opportunities to reverse this process and unleash the full potential
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pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 900 employees, the Department of Biomedicine is the largest department at the University. We