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of aging. High-frequency heart rate variability—a primary index of parasympathetic (vagal) activity—is roughly 80% lower at age 60 than at age 20, while resting sympathetic nerve activity approximately
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in sympathetic/parasympathetic balance; link sleep metrics to CAAN’s primary outcomes: LC structure and function (MRI), CSF and plasma biomarkers, proteomic markers of mitochondrial stress, daytime
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