Ubiquitin-Dependent Regulation of Stem Cell Fates

National Institute of Dental and Craniofacial Research, Bethesda, MD and surrounding area

We are seeking a highly motivated postdoctoral researcher to study ubiquitin-dependent regulation of stem cell maintenance and differentiation in normal and disease states. Our team is part of the National Institute of Dental and Craniofacial Research (NIDCR) embedded in the vibrant research community of the NIH’s main campus in Bethesda, Maryland.

Who we are:

We are a diverse team of scientists, who are fascinated by research centering around the post-translational modifier ubiquitin and how it regulates developmental cell-fate decisions. By combining human genetic and pluripotent stem cell approaches with biochemical, biophysical, and proteomic methods, we are studying the functions and mechanisms of particular ubiquitylation enzymes during different aspects of human development. Current projects are geared towards dissecting the role of CUL3-based E3 ligases and OTU deubiquitylases during brain and craniofacial development (Werner et al, 2015, Nature PMID: 26399832, Werner et al, 2018, Elife PMID: 29999490, Beck et al, Sci Adv 2021 PMID: 33523931), understanding the role of regulated ubiquitin activation during hematopoiesis (Beck et al, 2020, N Engl J Med PMID: 33108101), and identifying novel functions of ubiquitylation enzymes in stem cell maintenance and differentiation.

For more information please refer to our lab web page (https://www.nidcr.nih.gov/research/conducted-at-nidcr/intramural-research-labs/stem-cell-biochemistry/research ).

Who we are seeking:

We are looking for motivated and passionate researchers from diverse scientific, cultural, and personal backgrounds, who like to teach and learn in a collaborative, friendly, and hard-working environment. We are seeking creative and highly motivated candidates with Ph.D. and/or DDS or MD, strong verbal skills, experience with some of the methods we use (e.g. cell and molecular biology techniques, mammalian tissue culture, siRNA/shRNA, CRISPR, biochemical methods, proteomics, human genetics), and a previous track record of successful research. Bioinformatical skills and prior experience with hESC culture are a plus. Salary is commensurate with research experience and accomplishments.

Please submit your CV, bibliography, a brief statement of research interests, and the names of 2 to 3 references in a single PDF to:

Achim Werner, Ph.D.

Stadtman Investigator

Stem Cell Biochemistry Unit

National Institute of Dental and Craniofacial Research (NIDCR)

Building 30, 30 Convent Dr MSC 4340

Bethesda MD 20892-4340

This post will be available until April 25, 2022 or until filled.

NIH/NIDCR is dedicated to building an inclusive and diverse community in its training and employment programs.

DHHS and NIH are equal opportunity employers.