- Job Type: Support Staff - Union
- Bargaining Unit: SSA
- Regular/Temporary: Regular
- End Date if Temporary:
- Hours Per Week: 35
- Salary Range: 46,226.44
The Department of Microbiology & Immunology at the Columbia University Irving Medical Center seeks a Technician B with a background in biological research to join a dynamic research lab that conducts research into malaria. The research technician will play a key role in our investigations into mechanisms of Plasmodium falciparum parasite resistance to antimalarial drugs. The work will involve assessing resistance liabilities for antimalarial compounds in the preclinical stages of discovery or development. This work is supported by Medicines for Malaria Venture, a Geneva-based not for profit that leads the global antimalarial discovery and development pipeline. The technician will also be involved in projects to genetically map drug resistance traits in parasites through the use of genetic crosses between multidrug-resistant and -sensitive parasites. This project is supported by the National Institutes of Health and the Bill & Melinda Gates Foundation. In this capacity, the technician will be responsible for propagating cross progeny, testing their clonal integrity, conducting drug susceptibility assays with the progeny and parents, and helping assemble genetic maps to positionally locate the resistance-conferring genes. The technician will also help with testing candidate genes using CRISPR/Cas9 editing. The goals are to define genes that mediate resistance to antimalarial drugs used clinically in Southeast Asia and South America, where parasite resistance has emerged. Both projects are team-based studies involving postdoctoral scientists, graduate students, research technicians and the group leader Dr. David Fidock working as a tightly integrated team. The technician will also assist with general lab management including arranging exchange of materials with outside collaborators and ensuring equipment contracts are maintained.
This job offers the opportunity to be involved in cutting-edge research into defining the genetic basis of drug resistance for a disease that has a vast impact on the tropical regions of the world (with over 220 million cases yearly and over 260,000 deaths in children younger than five). The hired research technician will work in a vibrant environment of ~16 researchers recruited from around the world. Our group is well-funded, very interactive, and highly productive in publications per year (see Fidock Lab at www.fidock.org and https://pubmed.ncbi.nlm.nih.gov/?term=Fidock+D). Our research technicians typically continue into PhD, MD or MD/PhD programs upon having completed two years of research in the lab. We seek applicants who are highly motivated, self-sufficient, interactive, detail-oriented, passionate about infectious diseases research and global health, and who enjoy genetics and molecular and cell biology research.
To be considered, applicants should include their CV including a summary of research experience, transcript, and statement of interest.
Technician B will conduct:
Parasite culture work
Phenotypic analyses of cross progeny
Perform related duties as assigned
Requires a bachelor’s degree in Chemistry, Biology, Physics, or related science, or equivalent in education, training and experience.
Research experience and technical proficiency in molecular biology and/or cell culture is preferred but not essential.
- Must have undergraduate university course work in molecular biology, biochemistry, microbiology or genetics.
- Position will have contact with blood-borne pathogens (Plasmodium falciparum, routine Biosafety Level 2 precautions) and laboratory chemicals (none toxic)
Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.
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