TGen - Postdoctoral Fellow - Cancer Genomics - Phoenix, AZ

About TGen

TGen, the Translational Genomics Research Institute, is an affiliate of City of Hope.  We are an Arizona-based, nonprofit medical research institute dedicated to conducting groundbreaking research with life-changing results. We work to unravel the genetic components of common and complex diseases, including cancer, neurological disorders, infectious disease, and rare childhood disorders. By identifying treatment options in this manner, we believe medicine becomes more rational, more precise and, well, more personal.

At TGen, we are setting a new medical standard where the future of medicine is happening now. We are pioneers in deciphering the story a person’s genome has to tell. For individuals faced with a serious diagnosis, our scientists and clinicians have the ability to let a patients’ genome reveal its uniqueness in ways that are both powerful and transformative, especially when it comes to treating disease in a precise and individual manner.

TGen has had an important and highly positive impact in understanding the molecular drivers in cancer and other diseases and disorders, but more importantly, has been among the world’s leaders in applying this knowledge toward the treatment of patients. By strategically aligning ourselves with first-in-class medical providers, TGen provides direct benefit to those patients faced with limited options.

A hallmark of TGen is our belief that by utilizing the latest technologies and collaborating with the strongest of partners, we can develop better tools to increase our understanding of complex diseases and to better predict which treatments might be most effective, i.e., one-of-a-kind clinical trials (the right drug, at the right dose, at the right time).

TGen’s translational approach and our experience at leveraging genomic information in support of achieving more precise and personalized treatments augments your work in ways other institutes cannot. Our affiliation with City of Hope allows you to integrate your work with a growing health system committed to research with highest potential for improvements in patient care. In short, our science-led business-supported approach means there’s no better place to move your research forward.  If you’re looking for a job with purpose, you’ll find it at TGen.

Position Summary

The Postdoctoral Fellow will work on projects utilizing the latest technologies in long and short-read sequencing for analyses of structural variation and genome assembly. We are equipped with both the PacBio Revio and Oxford Nanopore Promethion long-read sequencers. Our team is skilled in library preparation for long-read sequencing and Hi-C using standard short reads, ensuring an ample supply of data to work with. The fellow will take part in the development of new tools for analyzing long reads and oversee the analysis of larger cohorts of samples.

The Barthel Laboratory is a cancer genomics lab focused on utilizing state-of-the-art genomic approaches to study the development and evolution of glial brain tumors (gliomas). The lab has a particular interest in the fundamental role of telomere dysfunction in glioma development, but is generally interested in all aspects of tumor evolution including but not limited to longitudinal studies of therapy response assessed by genomic analyses of tissue samples and liquid biopsies. We are looking for a talented, passionate and highly motivated postdoctoral fellow to work in the area of cancer genome evolution using long-read sequencing.

Basic education, experience and skills required for consideration:

·         PhD in Bioinformatics, Computer Science, Bioengineering, Computational Biology or related field and 2+ years of experience in an applied research environment in biomedical data analysis

·         Comfortable navigating Linux/UNIX based operating systems (eg. CentOS, Red Hat) and building shell scripts for data processing

·         Confident operating high-performance cluster systems via schedulers such as SLURM or Torque/PBS

·         Experience with scientific computing and data visualization tools such as R, Python or MATLAB and a good understanding of relevant statistics

·         Exposure to biological software development in one or more programming languages, such as Python, C++, Java or related languages

·         Experience building workflows using custom scripts and/or workflow management tools (eg. Nextflow, Snakemake, Common Workflow Language)

·         Good coding practices utilizing versioning (eg. Git, Subversion) and writing detailed documentation

·         Experience in biological data analysis and interpretation such as sequence alignment, data quality control, gene expression analysis, variant calling, phylogenetics

·         Familiarity with various biomedical databases such as UCSC Genome Browser, Ensembl, TCGA/ICGC, GTex and other databases

To Apply please click the link below:

https://recruiting.paylocity.com/recruiting/jobs/Details/1984382/The-Translational-Genomics-Research-Institute/Post-Doc-Fellow

Please direct all questions to [email protected]. Attach a letter describing your research interests and motivation to join our group. Include an academic CV detailing your past research experience, publication track record and (conference) presentations. We will start reviewing applications immediately and until the position is filled.