The Laboratory of Cellular and Molecular Biology of the Center for Cancer Research is seeking applications for an exceptional opportunity at the National Cancer Institute to work in the laboratory of Dr. Lawrence Samelson. The work in this laboratory uses techniques of mouse genetics, biochemistry, biophysics and molecular and cellular imaging to study the process of T cell activation. Efforts focus on pathways coupled to the T cell antigen receptor and those molecules, enzymes and adapters that are responsible for the early events in T cell activation. Experimental systems include mouse models, normal T cells and cell lines, and reconstitution of molecular pathways with recombinant proteins.
Candidates should have a strong record of scientific productivity as well as the ability, interest and initiative to design and perform studies that uncover the molecular mechanisms involved in T cell activation, differentiation, survival and function. The laboratory-based position requires expertise in T cell biology, differentiation, subsets, cytokines and activation. The candidate should have experience in mouse models relevant to these areas of interest and should have experience in performing in vivo experiments. Experience in preparing and maintaining animal research protocols and organizing, maintaining and supervising a mouse colony containing normal and genetically manipulated mice is expected. Experience in flow cytometry to define T cell subsets, state of differentiation and activation is required. The candidate also must be skilled in the biochemistry of T cell activation and the analysis of cytokines and transcription factors. Experience in T cell responses to tumors and/or infectious diseases is expected. Additional interests that are relevant include but are not limited to cancer immunology and immunotherapy.
Applicants should send a curriculum vitae and three letters of recommendation to Nancy Cruz, Building 37, 37 Convent Drive, Bldg. 37, Room 2066, 240-760-6360, firstname.lastname@example.org .
Selection for this position will be based solely on merit, with no discrimination for non-merit reasons such as race, color, religion, gender, sexual orientation, national origin, political affiliation, marital status, disability, age, or membership or non-membership in an employee organization. NIH encourages the application and nomination of qualified women, minorities and individuals with disabilities. NIH provides reasonable accommodations to applicants with disabilities. If you require reasonable accommodation during any part of the application and hiring process, please notify us. The decision on granting reasonable accommodation will be made on a case-by-case basis. This position is subject to a background investigation. Salary is commensurate with research experience.
DHHS, NIH and NCI are equal opportunity employers. The NIH is dedicated to building a diverse community in its training and employment programs.
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