Staff Scientist (Bioinformatics Analyst)

Updated: about 1 month ago
Location: Bethesda, MARYLAND

The Center for Cancer Research (CCR), National Cancer Institute (NCI)), National Institutes of Health (NIH) is recruiting a Staff Scientist (Bioinformatics Analyst) in the Laboratory of Cellular and Molecular Biology (LCMB) and Laboratory of Immune Cell Biology (LICB).


The successful candidate will provide bioinformatic support for multiple projects as a Staff Scientist to LCMB and LICB investigators, including the following:

  • The analysis and interpretation of high-throughput biomedical data generated by microarray, next-generation sequencing, and proteomics platforms
  • Contribute to a team effort in designing, developing and deploying robust workflows, as well as custom scripts, to support the analysis of high-throughput data
  • Mining proprietary and publicly available biological data to generate novel hypotheses or insights
  • Presenting analysis results, in a clear and concise manner, to scientific audience not familiar with bioinformatics

The Bioinformatics Analyst is expected to work effectively as a member of a team; coordinate activities among groups, interact with existing bioinformatic programs/cores in NIH and NCI/CCR, follow sound scientific practices and maintain effective documentation of activities and analyses. He is also expected to train fellows and students.


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Master's or PhD degree in life sciences/bioinformatics/math/physics/computer-related field from an accredited college according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for U.S. equivalency
  • In addition to or as part of educational. Requirements, a minimum of 3-5 years of related analytical or bioinformatics software development experience


  • Hands-on experience in processing sequencing, expression and other data utilizing bioinformatics tools
  • The ability to construct practical computational tools for data parsing, quality control, modelling and analysis for large-scale genetic or genomics datasets
  • Commitment to solving biological problems and communicating these solutions
  • Ability to multi-task across projects, work in collaborative environment and contribute to team projects
  • Experience in submitting data sets to public repositories
  • Management of large genomic data sets including integration with data available from public sources
  • Record of scientific achievements including journal publications and conference presentations

Expected Competencies:

  • Deep understanding of and hands-on experience in a) Genomic data processing and analysis of next generation sequencing (NGS) datasets, b) Mathematical and Statistical modeling, c) Systems
  • Biology and multi-omic data integration d) development and implementation of complex workflows in an HPC environment.
  • Ability to understand and analyze data from complex experimental designs
  • Expertise in algorithmic implementation, statistical programming and data manipulation, using e.g. R/Bioconductor, Matlab, Python, and a wide range of contemporary, open-source bioinformatics tools and database structures
  • Proficiency in R and/or Python, knowledge of one of other programming languages, e.g. Perl, Java and C/C++, is preferred.
  • Experience in the following areas: RNAseq, single-cell RNASeq, ATAC-seq, Chip-seq, alternative splicing analysis etc
  • Familiarity with public databases: NCBI GEO and SRA, Ensembl and UCSC genome, TCGA, cBioPortal, Broad FireHose

How to Apply:

Interested individuals should send a cover letter, curriculum vitae, brief summary of research interests and experience, and three letters of reference to: Dr. Ying Zhang, LCMB/CCR/NCI, 37 Convent Drive, 37/2056B, Bethesda. MD 20892-4250; E-mail: .

Selection for this position will be based solely on merit, with no discrimination for non-merit reasons such as race, color, religion, gender, sexual orientation, national origin, political affiliation, marital status, disability, age, or membership or non-membership in an employee organization. NIH encourages the application and nomination of qualified women, minorities and individuals with disabilities. NIH provides reasonable accommodations to applicants with disabilities. If you require reasonable accommodation during any part of the application and hiring process, please notify us. The decision on granting reasonable accommodation will be made on a case-by-case basis. This position is subject to a background investigation. Salary is commensurate with research experience.
DHHS, NIH and NCI are equal opportunity employers.

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