Staff Research Supervisor - Human Genetics

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  JOB DUTIES
  

The laboratory within the Department of Human Genetics works in the fields of epigenomics and neurodevelopmental disorders. Projects in the lab use epigenomic profiling of primary tissues and disease modeling using in vitro cell culture models. The incumbent will be primarily responsible for training and supervising junior lab members (e.g. SRAs) to perform experimental works. The incumbent will supervise two SRAs to perform single cell epigenomic experiments using the Beckman Biomek automation platform, performing key quality controls of the data. The incumbent will additionally supervise another SRA to generate spatial transcriptomics data using the Nanostring CosMx spatial molecular imager. The incumbent will further supervise another SRA to perform experiments to develop the photonic-indexing-sequencing approach. The incumbent will oversee the data generation for two NIH U01 projects awarded to the PI’s group and involves multiple collaborating labs at UCLA, in additional to external collaborators at other universities. Under the general supervision of the Principal Investigator, the incumbent will be responsible for undertaking research projects in collaboration with the Principal Investigator (PI) making independent contributions to research and experiments regarding the roles of gene regulation in brain development and psychiatric disorders using epigenomic approaches. The incumbent will perform epigenomic profiling experiments, making significant independent contributions in the design, troubleshooting, modification, and analysis of experiments and protocols. The incumbent will be responsible for implementing and performing a variety of new and ongoing experimental protocols, making significant and innovative contributions to the laboratory pertaining to complex experimental procedures of single-cell epigenomic profiling. The incumbent may provide training and direction and work cooperatively with other lab members, including doctoral and student lab assistants. The incumbent will independently write and publish manuscripts in journals, attend and present research results at laboratory meetings and academic conferences, and draft grant proposals. PAY RANGE: $ 24.28 – 48.04

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  JOB QUALIFICATIONS
  

REQUIRED: Experience in managing general responsibilities, such as ordering, maintenance of freezer programs and laboratory equipments; teaching students and other UCLA personnel basic molecular genetic methods, next-generation sequence analysis and new procedures. Training and experience in the library making and data analysis of next-generation sequencing data, including RNA sequencing and exome sequencing as well as in multiple genotyping techniques as well as molecular, biochemical and cellular research. Proficiency in the use of different computer clusters, servers, systems and languages, including as R, Python, SAS, SPSS, PLINK, Mendel, WGCNA, Sequencer, Unix-based programs, and PSQ96MA. Excellent written and verbal communication skills. Ability to perform independently organize and prioritize jobs (for self and assigned lab staff), manage time, and meet deadlines. Demonstrated ability to perform complex bioinformatics searches and comparisons in genome databases such as NCBI (National center of biotechnology Information), UCSC Genome Browser, HaploReg, BIOGPS, Genevar, PolyPhen, Sift. Knowledge in lab safety including waste management. Ability in designing study strategies. Demonstrated ability in designing experiments and/or laboratory techniques. Demonstrated ability to establish new laboratory procedures and protocols successfully. Demonstrated skills in analyzing information, problems, and procedures to define the problem and objective, identify relevant factors, formulate logical solution and follow up on problem resolution. Ability to perform molecular cloning and transformation of E. coli and eukaryotic cell lines. Preferred Ability to perform molecular biology and genetics procedures, i.e., SNP and microsatellite genotyping, microarray analyses (using both SNP genotyping and expression arrays), resequencing, PCR, RT-PCR, qRT-PCR, RNAse Protection Assay, genomic DNA analysis, preparation of recombinant plasmids, transient and stable transfections, in vitro transcription, mutagenesis and general recombinant DNA methods. Ability to analyze nextgeneration sequence data derived from DNA and RNA sequencing. PREFERRED: Ability to maintain excellent professional working relationships with all levels of individuals.Ability to perform molecular cloning and transformation of E. coli and eukaryotic cell lines.