CRISPR Scientist for Genomics Research I/II

Biochemistry and Biophysics

Full Time

64123BR

Job Summary

The Staff Research Associate I/II (SRA I/II) will be working in the Laboratory for Genomic Research (LGR) which is a new functional genomics center in which scientists use CRISPR/Cas9-based functional genomics tools to decipher biological functions of genes, identifying new drug targets and developing new technologies that will advance discovery in both academia and industry. In this position, he/she will be an integral member of a research team that is developing and using CRISPR-Cas functionalities and screens in human cell models to investigate the underlying causes of human disease biology and identify potential drug targets. The responsibilities can include culturing and maintaining human cell culture lines, performing flow cytometry and microscopy, performing standard molecular biology techniques, and performing basic statistical calculations.

Alternatively, the responsibilities can include extensive molecular biology work to develop new methods of sequencing sample preparation and/or supporting enabling technologies including scRNA-seq, high content imaging, and robotic-enabled pooled and arrayed screening.  Some time will be spent performing literature reviews and attending lab meetings/journal club meetings. Multiple openings are available.

Department Description

LABORATORY FOR GENOMIC RESEARCH
The Laboratory for Genomic Research (LGR) is a new functional genomics center on the UCSF Mission Bay campus. The LGR represents a novel hybrid model that brings together researchers from UC Berkeley, UC San Francisco, and GlaxoSmithKline under a single roof working on projects both together and independently.

The outputs of those research projects will be focused on deciphering biological functions of genes, identifying new drug targets and developing new technologies that will advance discovery in both academia and industry. The new laboratory will also be a resource for investigators at both UC campuses who will be able to access and use the LGR to answer their own biological and biomedical questions. At this time, we are beginning the staffing needed to fill several roles.

BIOCHEMISTRY & BIOPHYSICS
The Department of Biochemistry & Biophysics is a large teaching and research department within the School of Medicine (SOM). 

Required Qualifications

SRA I:
• BA/BS degree in natural sciences (preferably biology or chemistry) or a related science and knowledge of, or experience with, the basic techniques or methods required by the position; or an equivalent combination of education and experience
• Practical knowledge of basic molecular biology techniques and cloning
• Sterile technique and mammalian cell culture skills
• Working knowledge of MS Office (Word, Excel, PowerPoint)
• Math skills required for everyday calculations
• Ability to effectively use/maintain laboratory instruments such as flow cytometry instrument and/or cell sorter
• Ability to use internet as a resource for experimental tasks and literature searches
• Capability to learn/use basic statistical tools
• Excellent verbal and written communication skills

SRA II: In addition to the above,
• One or more years of recent, directly related work experience, utilizing the techniques or methods required by the position; or an equivalent combination of education and experience

Note: Classification and salary will depend on the qualifications of the applicant.

Preferred Qualifications

• Practical knowledge of CRISPR/Cas9 system
• Flow cytometry skills
• Drug dose titration skills

About UCSF

The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world’s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.

Pride Values

UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence – also known as our PRIDE values.

In addition to our PRIDE values, UCSF is committed to equity – both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available at diversity.ucsf.edu

Join us to find a rewarding career contributing to improving healthcare worldwide.

Equal Employment Opportunity

The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.

Job Code and Payroll Title

009617 SRA 2 NEX

Job Category

Research and Scientific

Bargaining Unit

University Professional Technical Employees – Research Support Professionals Unit (UPTE-RX)