Senior Scientist, Protein Sciences

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Senior Scientist in the Cellular, Genomic, and Protein Sciences (CGPS) department, you will be at the center of our protein expression and purification operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be responsible for construct design and purification from bacterial, insect, and mammalian cells. With your deep knowledge of the discipline, you will be recognized as a technical expert and a scientific contributor who routinely partners with and mentors junior colleagues within the department and across therapeutic areas. Your innovation and creativity in developing novel processes and new ideas will be frequently used to drive decision making impact across the portfolio and establish a world-leading Protein Sciences pipeline to serve a world-leading Drug Discovery pipeline.

How You Will Achieve It

• Represent Protein Sciences at the project team level, helping to guide new targets from gene to screen.
  
• Troubleshoot scientific and technical challenges. Mentor more junior scientists to do the same.
  
• Design constructs for expression in bacterial, insect, and mammalian cells to produce high quality recombinant proteins, protein complexes, and RNA.
  
• Purify and characterize recombinant proteins to enable high throughput assays, biophysical assays, and structural efforts.
  
• Prepare internally reviewed technical reports, make oral presentations to scientists and management, and publish externally.
  

Qualifications

Must-Have

• Bachelor's Degree with 9+ years of experience OR Master's degree with 7+ years of Experience or PhD with no experience
  
• Strong documented experience in protein biochemistry, protein purification, protein modification using enzymatic and chemical methods, and biophysical characterization.
  
• Experience with antibody engineering in developing ImmunoTherapeutics.
  
• Experience and knowledge in operation of modern mass spectrometry platforms and associated data analysis packages.
  
• Expert level knowledge of assay development methodologies for binding and functional activity
  
• Ability to deliver results on goals in a fast-paced, dynamic and highly multi-tasking environment.
  
• Excellent written and oral communication skills
  

Nice-to-Have

• Experience with methods for successful purification of integral membrane proteins and nanoparticles (SMALP,, Nanodisc, etc)
  
• Computational skills using Biacore, Octet, Microsoft Excel, and other applications designed to evaluate, process, and manage biosensor data
  
• Protein engineering and/or thermal stabilization experience
  

PHYSICAL/MENTAL REQUIREMENTS

• Sitting, standing, lifting, bending, and walking.
  
• Ability to perform practical laboratory bench work and work on a computer (while standing or sitting).
  
• Ability to perform mathematical calculations and interpret data.
  

Other Job Details

• Relocation support available.
  
• Work Location Assignment:On Premise.
  

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development