Senior Scientist, Molecular Discovery

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

ROLE SUMMARY

Pfizer's BioMedicine Design Biotherapeutic Expression and Purification group (BEP) is seeking a cell biologist or process engineer in the Discovery Bioprocess group. Qualified candidate will play an essential role in a high-energy protein expression research laboratory.

The Expression group is responsible for non-GMP protein drug lead generation, supporting the various Pfizer research units and their pre-clinical therapeutic in-vitro and in-vivo needs.

The successful candidate will bring to this role:

• Knowledge and Experience of running bioreactors, single-use or CIP. Mammalian cell culture.
• Understanding of cellular bioprocess and implications in protein production.
• Excellent communication skills, ability to work on several projects in multi-department collaborative matrix, presenting results and providing updates at group/project meetings.

ROLE RESPONSIBILITIES

• Scaleup of CHO pools in disposable 5-100L bioreactors
• Generate stable CHO cell lines, cell banks, expression assessments
• Depth filtration of conditioned media
• Capture data in electronic notebook and routinely provide updates to project teams.
• Work with the head of group, project leads, and other senior group members on experimental design and providing data packages with the goal of identifying and advancing best strategies
• Successful candidate will be involved in the design and execution of projects with the ability to operate independently
• Work closely with multidisciplinary teams including therapeutic discovery teams, Molecular biology, BEP Purification group, research units, and BTxPS
• Occasional travel to Cambridge, MA

BASIC QUALIFICATIONS

• A PhD with 0-3 years of relevant experience, MS with 7+ years, BS with 15+ years of relevant experience in Biomedical Science, Chemical Engineering, Biology or a related discipline along with a solid understanding of cellular bioprocesses involved in biotherapeutic production.
• Strong understanding of controlled bioreactor operations. Disposable or SIP/CIP reactors.
• Extensive experience with suspension antibiotic-free mammalian cell culture and stable cell line generation
• Strong communication skills, written, oral and organizational skills.
• People Mentorship experience
• Prior experience in therapeutic protein discovery and biochemistry research

PREFERRED QUALIFICATIONS

• Pharmaceutical industry experience highly preferred
• Knowledge of DeltaV/Trubio control systems.
• Experience with Process Optimization, comprehension of statistics and experimental design.
• Protein Determination using HPLC, Western blot analysis
• Familiarity with Unicorn, Empower and Chemstation
• Ability to run Flow Cytometry independently using FACS Diva and/or FlowJo
• Proven track record in project delivery

PHYSICAL/MENTAL REQUIREMENTS

Ability to lift 50 lbs

Additional Information:

• Relocation support available
• Work Location Assignment:On Premise
• Last Day to Apply: February 29, 2024

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development