Senior Research Scientist

Senior Research Scientist
Sarcoma Cancer Research Center | Singer Laboratory @MSK

Memorial Sloan Kettering Cancer Center, New York, NY

Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a comprehensive cancer center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians and other health care workers.

Dr. Singer’s Sarcoma Research Lab is seeking an experienced Scientist to join their NIH funded laboratory dedicated to gene target identification and drug discovery in soft tissue sarcoma through a genome-wide genetic and functional analysis.  The overall goal of the lab is to perform a comprehensive molecular genetic and functional analysis of soft tissue sarcoma, so as to elucidate the mutational programs and pathways involved in sarcomagenesis and to identify novel therapeutic targets. Sarcoma tissue samples and cell lines are subjected to a multiplatform genome-wide characterization of expression of protein-coding genes and microRNAs, DNA copy number changes, activating mutations, gene rearrangements and methylation profiling.  These data are then used to identify both genetically distinct subtypes of sarcoma and molecular signatures associated with tumor morphology, grade, recurrence, and survival.  To identify potential therapeutic targets, our lab screens the genes and microRNAs in these signatures for involvement in proliferation, differentiation, and survival of sarcoma cell lines.  Potential targets are validated by functional assays in additional cell lines and in xenograft models.  Results will be translated into new therapeutics for soft tissue sarcoma.

The ideal candidate should have:

• Ph.D. or equivalent in biological science Proficiency in molecular and cell biology and one or more of the following areas: Computational biology/NGS data analysis Cancer biology Genetically engineered mouse models.

A strong publication record (1st author peer-reviewed publications) At least 5 years of experience  

Please send CV, bibliography, brief statement of research interests and names of 3 references via email (Including #SingerResearch in the subject line) to: Russell Holmes Surgery Research Lab Operations Manager [email protected]  

MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision. 

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