Senior Research Investigator (Department of Neuroscience)

Details

Posted: 10-Apr-24

Location: Philadelphia, Pennsylvania

Type: Full-time

Salary: Open

Categories:

Academic/Faculty
Allied Health

Internal Number: 5168041

Senior Research Investigator (Department of Neuroscience)
University Overview
The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.
Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.
The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.
Posted Job Title
Senior Research Investigator (Department of Neuroscience)
Job Profile Title
Research Investigator, Senior
Job Description Summary
The Senior Research Investigator (SRI) will act in a leadership role, overseeing and designing advanced experiments. He/She/They will assist the Principal Investigator and play a leading role in developing a research project that uses mouse models and human induced pluripotent stem cells (hiPSCs)-derived 2D and 3D models to study epigenetic and epitranscriptomic mechanisms by which neurons repair DNA damage. Results derived from this study potentially will not only provide new insights into how neuronal cells maintain genome stability but also help in devising novel therapeutics for neurological disorders such as Alzheimer's disease.
The SRI will play a crucial role in all aspects of research products including development, implementation, and data analysis. In the development stage, the SRI will assess proposed projects by conducting feasibility studies to provide valuable input regarding efficiency, timeline, and study design. In the implementation stage, he/she will supervise and perform the projects. This includes overseeing workflow and productivity of personnel and providing training to them on specific methods as necessary. Finally, the SRI will be responsible for data analysis, preparation of manuscripts, liaising with external partners, and presenting research findings through various forums. The SRI must demonstrate the ability to analyze and present data in professional 'publication ready' format and to be able to independently prepare manuscripts and grant writings for submission.
Job Description
Job Responsibilities
The successful applicant will have extensive experience in the fields of neuroanatomy, cellular and molecular biology, biochemistry, iPSC culture, human genetics, neuroscience, epigenetics, epitranscriptomics and bioinformatics. To this end, we seek a candidate who will lead every aspect of the project.
The SRI will:

• Design and implement experiments under the supervision of Dr. Hongjun Song.
  
• Perform immunostaining and analyze imaging data.
• Package lentivirus and AAV.
• Stereotaxic injection of virus expressing shRNA against target genes in target mouse brain region.
• Differentiate isogenic hiPSC lines into 2D cortical and hippocampal neurons and 3D cortical and hippocampal organoids.
• Perform RNA-seq, RIP-seq, MapR, ChIP-seq assays with mouse brain tissue and human neurons derived from iPSCs.
• Prepare library for sequencing and analyze sequencing data at both the single and population levels.

Position is contingent on continued grant funding.
Qualifications

• Doctor of Medicine, Doctor of Philosophy, and 5 to 7 years of postdoctoral experience is required.
  

Job Location - City, State
Philadelphia, Pennsylvania
Department / School
Perelman School of Medicine
Pay Range
$36,368.00 - $100,000.00 Annual Rate
Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and market factors and grade profile.
Affirmative Action Statement
Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.
Special Requirements
Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
University Benefits

• Health, Life, and Flexible Spending Accounts: Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.
  
• Tuition: Take advantage of Penn's exceptional tuition benefits. You, your spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other institutions.
  
• Retirement: Penn offers generous retirement plans to help you save for your future. Penn's Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options through TIAA and Vanguard.
  
• Time Away from Work: Penn provides you with a substantial amount of time away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with family-whatever your personal needs may be.
  
• Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services received at home, in the community or in a nursing facility. If you apply when you're newly hired, you won't have to provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to underwriting.
  
• Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as they balance the competing demands of work and personal life. That's why we offer a wide variety of programs and resources to help you care for your health, your family, and your work-life balance.
  
• Professional and Personal Development: Penn provides an array of resources to help you advance yourself personally and professionally.
  
• University Resources: As a member of the Penn community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University's libraries and athletic facilities, or visit our arboretum and art galleries. There's always something going on at Penn, whether it's a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few examples. As a member of the Penn community, you're right in the middle of the excitement-and you and your family can enjoy many of these activities for free.
  
• Discounts and Special Services: From arts and entertainment to transportation and mortgages, you'll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.
  
• Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.
  
• Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.
  
• Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.
  

To learn more, please visit: https://www.hr.upenn.edu/PennHR/benefits-pay
To apply, visit https://wd1.myworkdaysite.com/en-US/recruiting/upenn/careers-at-penn/job/Clinical-Research-Building---1st-Floor/Senior-Research-Investigator--Department-of-Neuroscience-_JR00088633
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About University of Pennsylvania
Penn has a long and proud tradition of intellectual rigor and pursuit of innovative knowledge, begun by Benjamin Franklin in 1740. That tradition lives today through the creativity, entrepreneurship, and engagement of our faculty, students, and staff. Academic life at Penn is unparalleled, with an undergraduate student body of 10,000 from every U.S. state and around the world. The entering class of 2015 is the most talented and diverse in Penn's history. Consistently ranked among the top 10 universities in the country, Penn welcomes an additional 10,000 students to our top-ranked graduate and professional schools.
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