Senior Associate Scientist, LCMS Biomeasures

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best - in - class medicines to patients around the world.

What You Will Achieve

Join us as a Senior Associate Scientist for this exciting opportunity in the Biomeasures LCMS group in Pfizer Andover applying protein LCMS bioanalysis to transformative mRNA/LNP and biotherapeutics projects. You will contribute to the development of protein bioanalytical mass spectrometry assays to measure concentrations of targets of biotherapeutics in a variety of biological matrices as well as transgene protein expression from mRNA-LNP therapies. This is an opportunity to leverage your expertise in sample preparation and enrichment techniques including antibody-free or immunoaffinity methods in conjunction with LCMS-based detection. The measured parameters from preclinical studies or human specimens are input parameters to mechanistic models supporting target evaluation, dose, or efficacy projections. You will join a state-of-the-art laboratory with deep expertise in protein quantification by mass spectrometry and bring emerging bioanalytical expertise, ideally some background in protein biochemistry, expertise in triple quadrupole or high resolution quantitative mass spectrometry. You will work in project teams and interacts with modelling & simulation experts, project leads, biologists, and protein engineers.

How You Will Achieve It

• Responsible for experiments that lead to the development, qualification and implementation of transgene protein, target bio measure and pharmacodynamic biomarker assays using mass spectrometry in support of discovery and translational projects.
  
• Works with group lead or other bio measure team members and project team members to accomplish goals.
  
• Participates in technology development and implementation by exploring new workflows to expand the group's biomarker bioanalytical capabilities.
  
• Participate in all phases of mass spectrometry laboratory operations including technology evaluations, the development of sample preparation and separation methods, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making.
  
• Ensure all tasks and responsibilities are carried out according to scientific and ethical standards e.g., responsible for electronic notebook record keeping, QC and peer review of data and reports.
  

Qualifications:

Must-Have

• Qualified applicants hold a BS/BA with 3+ years of experience in bio bioanalytical or MS with 0+ years of relevant work experience, ideally mostly in industry.
  
• General familiarity with LCMS technology and bioanalytical chemistry quantification assay development.
  
• Familiarity in operation of LCMS instrumentation and associated data analysis software
  

Qualifications:

Nice-to-Have

• Expertise in quantitative tissue bioanalysis and extraction of large molecule methodology.
  
• Experience in the operation and troubleshooting of LCMS instrumentation and associated operating/data analysis software including Skyline, Analyst and Xcalibur.
  
• Expertise in biological sample preparation techniques (immunoaffinity, tryptic digestion, tissue processing, conjugation, etc) of various biofluids
  
• Some understanding of protein biochemistry.
  
• Ability to work both independently and as part of a team, multitasking multiple programs.
  

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONM

ENT REQUIREMENTS

• Lab based position requiring performing all typical laboratory related activities.
  
• Based in Andover
  
• Occasional travel to Cambridge (Kendal Square) is required, depending on project needs.
  

Other Job details:

• Work Location Assignment:On Premise
  
• Last Day to Apply: March 9th, 2023
  

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development