Scientist - Antibody Production & Engineering

Posted: 06-May-23

Location: Boston, Massachusetts

Salary: Open

Internal Number: 2022-29239

Dana-Farber Cancer Institute is seeking an experienced PhD-level scientist to join IMPACT, a new pre-clinical research group with the mission to streamline ???discovery to translation??? of antibody-based immunotherapies for cancer. The IMPACT team will work closely with DFCI PIs as well as external antibody discovery partners to develop and implement the production and ??functional screening of antibody ???hits??? as well as the engineering of hits to generate ??potential therapeutic bispecifics and CAR T-cell immunotherapies. The candidate should be an exceptionally motivated individual with experience in the areas of antibody production, antibody discovery and/or antibody engineering and biophysical characterization.

The Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allied in the common mission of conquering cancer. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to all patients; we conduct research that advances treatment; we educate tomorrow???s physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.??

• Develop and implement a platform for the scaled production and characterization (i.e. SEC, HIC, etc.) of monospecific and multispecific antibodies.
• Design and execute experiments to evaluate antibody ???hits??? for binding (i.e. Biacore-SPR or Octet-BLI), function and biophysical properties.
• Design and execute workflows for producing and functionally screening antibodies and CARs to identify leads for clinical translation.
• Collaborate with team members and across groups to implement best practices for the operation and maintenance of immunotherapy production, screening and engineering platforms.Co-author technical reports and manuscripts for publication and/or present at internal and external meetings.
• Operate and maintain laboratory instruments related to the production, characterization and engineering of antibodies and CARs.
• Evaluate and develop??novel approaches to antibody and CAR screening including library-based approaches and/or the use of automation.??

• PhD with experience in in antibody discovery, screening and/or protein engineering.?? A candidate with a M.S. degree and substantial experience (i.e. >7 years) may also be considered for this role.?? Industry research experience a plus.?? ??
• Strong track record, hands-on experience and in-depth knowledge of protein production and characterization techniques (i.e. SEC, HIC, etc.), label-free binding technologies like SPR or BLI and/or developability screening of antibodies
• Exceptionally??self-motivated.
• Excellent communication (written and verbal) and troubleshooting skills as well as an ability to work with a wide variety of collaborators.??
• Outstanding planning, organizational, multi-tasking skills.
• Must consider attention to detail a strength.??
• Ability to work within a fast-paced team environment.??

Only applicants that submit a cover letter and a detailed CV will be considered.?? Following a pre-screen interview, candidate will be requested to provide the contact information for three references as well.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.?? As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.?? Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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About Dana-Farber Cancer Institute
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to under-served members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
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