Research Technician (Shpargel Lab)

University of North Carolina at Chapel Hill, United States

Updated: 11 months ago
Location: Chapel Hill, NORTH CAROLINA
Job Type: FullTime
Deadline: 24 May 2023

Posting Information
Posting Information


Department Genetics - 423501
Career Area Research Professionals
Posting Open Date 05/17/2023
Application Deadline 05/24/2023
Position Type Temporary Staff (SHRA)
Position Title Research Technician (Shpargel Lab)
Position Number 20055854
Vacancy ID S021501
Full-time/Part-time Full-Time Temporary
Hours per week 40
Work Schedule
Position Location North Carolina, US
Hiring Range 20.00 - 25.00
Proposed Start Date 06/05/2023
Estimated Duration of Appointment 6 months not to exceed 11 months

Position Information


Primary Purpose of Organizational Unit
The UNC School of Medicine has a rich tradition of excellence and care. Our mission is to improve the health and well being of North Carolinians, and others whom we serve. We accomplish this by providing leadership and excellence in the interrelated areas of patient care, education, and research. We strive to promote faculty, staff, and learner development in a diverse, respectful environment where our colleagues demonstrate professionalism, enhance learning, and create personal and professional sustainability. We optimize our partnership with the UNC Health System through close collaboration and commitment to service. 
OUR VISION
Our vision is to be the nation’s leading public school of medicine. We are ranked 2nd in primary care education among all US schools of medicine and 5th among public peers in NIH research funding. Our Allied Health Department is home to five top-ranked divisions, and we are home to 18 top-ranked clinical and basic science departments in NIH research funding.
OUR MISSION
Our mission is to improve the health and well-being of North Carolinians and others whom we serve. We accomplish this by providing leadership and excellence in the interrelated areas of patient care, education, and research.
Patient Care: We will promote health and provide superb clinical care while maintaining our strong tradition of reaching under-served populations and reducing health disparities across North Carolina and beyond.
Education: We will prepare tomorrow’s health care professionals and biomedical researchers by facilitating learning within innovative curricula and team-oriented inter-professional education. We will cultivate outstanding teaching and research faculty, and we will recruit outstanding students and trainees from highly diverse backgrounds to create a socially responsible, highly skilled workforce.
Research: We will develop and support a rich array of outstanding health sciences research programs, centers, and resources. We will provide infrastructure and opportunities for collaboration among disciplines throughout and beyond our University to support outstanding research. We will foster programs in the areas of basic, translational, mechanistic, and population research.
Position Summary
The Shpargel Laboratory within the UNC Genetics Department is seeking a Research Technician with a background in molecular biology. Histone post-translational modifications can impact expression of large sets of genes during cellular differentiation. The enzymes that catalyze these modifications are mutated in human craniofacial and skeletal disorders. The focus of this study involves utilizing genetic, molecular, and biochemical applications to study the mechanisms by which mutation of histone modifying enzymes regulate bone and cartilage development. Current projects are examining the roles of these enzymes in balancing stem cell biology with osteoblast and chondrocyte differentiation. Join an exciting, collaborative research environment utilizing technologies at the forefront of genetic and genomic exploration.
Minimum Education and Experience Requirements

Demonstrated possession of the competencies necessary to perform the work.
Required Qualifications, Competencies, and Experience
Candidate should possess laboratory technical experiences which includes some combination of the following: mammalian cell culture, PCR, genotyping, chromatin immunoprecipitation, and tissue histology.
Preferred Qualifications, Competencies, and Experience
The project will analyze molecular mechanisms of bone and cartilage development in mice carrying mutations in histone modifying enzymes. Experience in molecular biology, mammalian cell culture, or mouse developmental biology is preferred. This project will collect mutant cell culture or dissected mouse tissues of interest, perform genotyping, and prepare samples for downstream next generation sequencing to analyze gene expression (RNA-seq) or histone profiles (ChIP-seq). The project will utilize a variety of genetic approaches to mutate and assay gene function in cell culture. We will be performing CRISPR screens and proteomics to identify factors that co-function with histone modifying enzymes.
Special Physical/Mental Requirements
Campus Security Authority Responsibilities

Not Applicable.
Special Instructions
Quick Link https://unc.peopleadmin.com/postings/257218
Temporary Employment Policies

Temporary Employment Policies


Posting Contact Information


Office of Human Resources Contact Information

If you experience any problems accessing the system or have questions about the application process, please contact the Office of Human Resources at (919) 843-2300 or send an email to [email protected]

Please note: The Office of Human Resources will not be able to provide specific updates regarding position or application status.
Equal Opportunity Employer Statement

The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.

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