Research Technician - Mass Spectrometry

Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147

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The Howard Hughes Medical Institute’s Janelia Research Campus is a pioneering research center in Ashburn, Virginia, where scientists pursue fundamental questions in the life sciences. Our integrated teams of biologists, computational scientists, and tool-builders innovate research practices and technologies to solve biology’s deepest mysteries. HHMI launched Janelia in 2006, establishing an intellectually enriching environment for scientists to do creative, collaborative, hands-on work. We share our methods, results, and tools with the scientific community.

About the role:

We are seeking an experienced and organized Research Technician III with experience in proteomics, metabolomics and/or lipidomics to join our dynamic team. The successful candidate will play a key role in executing mass spectrometry sample preparation, LC-MS/MS system operation, data analysis, and contributing to the development of new methodologies and protocols.  This would be an excellent role for a scientifically minded professional with at least two years of mass spectrometry experience who enjoys helping researchers solve their scientific puzzles and contribute their sound hands-on skills in an outstanding academic research facility.

About Department:

The mass spectrometry department at HHMI, Janelia Research Campus is a new shared resource which is dedicated to advancing scientific research and innovation in the field of proteomics, metabolomics, lipidomics and many more. We are equipped with state-of-the-art instruments and solutions to facilitate the study of the dynamics, structures, functions, and interactions of various biomolecules which may correlate to cellular dynamics, neural and behavioral mechanisms.

What we provide:

• A competitive compensation package, with comprehensive health and welfare benefits. 

• A continuous learning environment and opportunities for professional development and career advancement. 

• Collaborative and innovative work environment. 

• Chance to make a meaningful impact on scientific research and discovery. 

What you’ll do:

Working under direct supervision of the department director, you will perform routine and increasingly sophisticated laboratory tasks and procedures and develop technical expertise in one or more areas relevant to mass spectrometry.

• Perform sample preparation including biomolecule extractions, protein digestions, isotope labeling of biomolecules, LC fractionation, SPE sample cleanup and related sample purifications. 

• Operate and maintain state-of-the-art mass spectrometry instruments available onsite. 

• Analyze proteomics, metabolomcis or lipidomics data using software packages and bioinformatics tools. 

• Keeps accurate and detailed records of experimental procedures, data analysis results, and assists in identifying and troubleshooting unexpected results. 

• Report on weekly quality control assessments of sample preparation and instrument performance. 

• Contribute to the optimization and validation of proteomics, metabolomics and lipidomics protocols and methodologies. 

• Maintain laboratory inventories and support laboratory operations. 

• May train junior laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment, and safety procedures. 

• Perform all other related duties as needed. 

What you bring:

• Minimum of a bachelor’s degree in chemistry, biochemistry or a closely related field. 

• At least 4 years (Bachelor of Science) or 2 years (Master of Science) of hands-on experience performing proteomics or metabolomics sample preparation, operating, and/or maintaining LC-MS/MS systems. 

• Proficiency in using mass spectrometer operating software, particularly Thermo Xcalibur is preferred. Experience in data analysis software such as Proteome Discoverer, Compound Discoverer, MaxQuant, and Skyline will be an asset. 

• Must have digital literacy to include, but not limited to, Excel, Word and PowerPoint. 

• Enthusiastic and self-motivated individual with the ability to work independently with minimal supervision.

• Strong organizational skills, customer service skills, and time management skills. 

• Strong verbal and written communication skills. 

• Strong attention to detail and recordkeeping skills. 

• Ability to function effectively as a member of a team.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances or other hazardous materials.

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.  Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.

Compensation and Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more. 

Compensation Range

$52,140.00 (minimum) - $65,200.00 (midpoint) - $84,700.00 (maximum)

Pay Type:

Annual

HHMI’s salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal equity when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range.

HHMI is an Equal Opportunity Employer